[Directed cleavage of the 16S rRNA molecule at a single internucleotide bond]. / Napravlennoe razrezanie molekul 16S rRNK po edinichnoi mezhnukleotidnoi sviazi.

Cleavage of 16S ribosomal RNA (rRNA) from E. coli "hammerhead" type ribozymes as well as by RNAase iI in the presence of "hymeric" (2'-deoxy-F-thymidine containing) oligonucleotides has been studied. The conditions for the cleavage of a desired single internucleotide bond have been found for a large molecule with a very complicated secondary and three-dimensional structure.