1.
Pragmat Obs Res
; 2: 13-18, 2011.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27774010
RESUMO
In symptomatic bone metastases with significant pain, refractory to standard analgesics and radiotherapy, loading dose zoledronic acid (ZA) represents a simple and nontoxic treatment to obtain significant pain relief in a very short time. Its analgesic effect is limited to patients with massive osteoclast activation with high initial serum C-telopeptide (CTX). The pain reduction is proportionally correlated with the reduction of CTX.