RESUMO
Overproduction of IL-18 has been described in chronic urticaria. To evaluate free IL-18 and IL-33 in chronic spontaneous urticaria (CSU). IL-18, its inhibitor IL-18BP, IL-33 and its soluble receptor ST2 (sST2) were measured (ELISA) in the sera of 73 CSU patients. Free IL-18 was calculated (law of mass action). Autologous serum skin test (ASST) was performed in all patients. Total IL-18, IL-18BP and free IL-18 serum levels were significantly higher in CSU than in controls. IL-18 and IL-18BP increased significantly in both ASST-positive and negative subgroups. Free IL-18 resulted significantly higher in the ASST-negative, but not in the ASST-positive subgroup. No differences in IL-33/sST2 levels were detected between CSU and controls. Increased levels of free IL-18 and IL-18BP, but not IL-33, was detected in CSU. Whether IL-18 up-regulation is a consequence of inflammation or one of the causes of the pathology needs to be addressed.
Assuntos
Interleucina-18/sangue , Interleucinas/sangue , Urticária/sangue , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Doença Crônica , Feminino , Humanos , Peptídeos e Proteínas de Sinalização Intercelular/metabolismo , Interleucina-33 , Masculino , Pessoa de Meia-Idade , Adulto JovemAssuntos
Angioedema/tratamento farmacológico , Anti-Inflamatórios não Esteroides/uso terapêutico , Antagonistas de Receptor B2 da Bradicinina , Bradicinina/análogos & derivados , Angioedema/imunologia , Angioedema/metabolismo , Anti-Inflamatórios não Esteroides/administração & dosagem , Bradicinina/administração & dosagem , Bradicinina/metabolismo , Bradicinina/uso terapêutico , Humanos , Injeções Subcutâneas , Masculino , Pessoa de Meia-Idade , Receptor B2 da Bradicinina/metabolismoRESUMO
We describe a 36 year old male patient affected by microscopic polyangiitis; he was treated with corticosteroic and cyclophosphamide pulses obtaining clinical improvement and remission and acute flogistic index normalization. The peculiar aspect is a stable remission during a four years follow up; the only relapse was controlled with low dose of corticosteroids.