Nonlinear Effects in Black Hole Ringdown.

We report evidence for nonlinear modes in the ringdown stage of the gravitational waveform produced by the merger of two comparable-mass black holes. We consider both the coalescence of black hole binaries in quasicircular orbits and high-energy, head-on black hole collisions. The presence of nonlinear modes in the numerical simulations confirms that general-relativistic nonlinearities are important and must be considered in gravitational-wave data analysis.

Bekenstein-Hod Universal Bound on Information Emission Rate Is Obeyed by LIGO-Virgo Binary Black Hole Remnants.

Causality and the generalized laws of black hole thermodynamics imply a bound, known as the Bekenstein-Hod universal bound, on the information emission rate of a perturbed system. Using a time-domain ringdown analysis, we investigate whether remnant black holes produced by the coalescences observed by Advanced LIGO and Advanced Virgo obey this bound. We find that the bound is verified by the astrophysical black hole population with 94% probability, providing a first confirmation of the Bekenstein-Hod bound from black hole systems.

No tension between assembly models of super massive black hole binaries and pulsar observations.

Pulsar timing arrays are presently the only means to search for the gravitational wave stochastic background from super massive black hole binary populations, considered to be within the grasp of current or near-future observations. The stringent upper limit from the Parkes Pulsar Timing Array has been interpreted as excluding (>90% confidence) the current paradigm of binary assembly through galaxy mergers and hardening via stellar interaction, suggesting evolution is accelerated or stalled. Using Bayesian hierarchical modelling we consider implications of this upper limit for a range of astrophysical scenarios, without invoking stalling, nor more exotic physical processes. All scenarios are fully consistent with the upper limit, but (weak) bounds on population parameters can be inferred. Recent upward revisions of the black hole-galaxy bulge mass relation are disfavoured at 1.6σ against lighter models. Once sensitivity improves by an order of magnitude, a non-detection will disfavour the most optimistic scenarios at 3.9σ.

Regulation of the Flt3 Gene in Haematopoietic Stem and Early Progenitor Cells.

The MYB transcription factor plays critical roles in normal and malignant haematopoiesis. We previously showed that MYB was a direct activator of FLT3 expression within the context of acute myeloid leukaemia. During normal haematopoiesis, increasing levels of FLT3 expression determine a strict hierarchy within the haematopoietic stem and early progenitor compartment, which associates with lymphoid and myeloid commitment potential. We use the conditional deletion of the Myb gene to investigate the influence of MYB in Flt3 transcriptional regulation within the haematopoietic stem cell (HSC) hierarchy. In accordance with previous report, in vivo deletion of Myb resulted in rapid biased differentiation of HSC with concomitant loss of proliferation capacity. We find that loss of MYB activity also coincided with decreased FLT3 expression. At the chromatin level, the Flt3 promoter is primed in immature HSC, but occupancy of further intronic elements determines expression. Binding to these locations, MYB and C/EBPα need functional cooperation to activate transcription of the locus. This cooperation is cell context dependent and indicates that MYB and C/EBPα activities are inter-dependent in controlling Flt3 expression to influence lineage commitment of multipotential progenitors.

Demonstrating the feasibility of probing the neutron-star equation of state with second-generation gravitational-wave detectors.

Fisher matrix and related studies have suggested that, with second-generation gravitational-wave detectors, it may be possible to infer the equation of state of neutron stars using tidal effects in a binary inspiral. Here, we present the first fully Bayesian investigation of this problem. We simulate a realistic data analysis setting by performing a series of numerical experiments of binary neutron-star signals hidden in detector noise, assuming the projected final design sensitivity of the Advanced LIGO-Virgo network. With an astrophysical distribution of events (in particular, uniform in comoving volume), we find that only a few tens of detections will be required to arrive at strong constraints, even for some of the softest equations of state in the literature. Thus, direct gravitational-wave detection will provide a unique probe of neutron-star structure.

Itga2b regulation at the onset of definitive hematopoiesis and commitment to differentiation.

Product of the Itga2b gene, CD41 contributes to hematopoietic stem cell (HSC) and megakaryocyte/platelet functions. CD41 expression marks the onset of definitive hematopoiesis in the embryo where it participates in regulating the numbers of multipotential progenitors. Key to platelet aggregation, CD41 expression also characterises their precursor, the megakaryocyte, and is specifically up regulated during megakaryopoiesis. Though phenotypically unique, megakaryocytes and HSC share numerous features, including key transcription factors, which could indicate common sub-regulatory networks. In these respects, Itga2b can serve as a paradigm to study features of both developmental-stage and HSC- versus megakaryocyte-specific regulations. By comparing different cellular contexts, we highlight a mechanism by which internal promoters participate in Itga2b regulation. A developmental process connects epigenetic regulation and promoter switching leading to CD41 expression in HSC. Interestingly, a similar process can be observed at the Mpl locus, which codes for another receptor that defines both HSC and megakaryocyte identities. Our study shows that Itga2b expression is controlled by lineage-specific networks and associates with H4K8ac in megakaryocyte or H3K27me3 in the multipotential hematopoietic cell line HPC7. Correlating with the decrease in H3K27me3 at the Itga2b Iocus, we find that following commitment to megakaryocyte differentiation, the H3K27 demethylase Jmjd3 up-regulation influences both Itga2b and Mpl expression.