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1.
Parkinsonism Relat Disord ; 117: 105897, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-37931350

RESUMO

INTRODUCTION: With the current demographic transition, it is estimated that by 2050 Brazil will have a population of 90 million people aged 60 years or more, and in parallel Parkinson's disease (PD) will bring a considerable economic burden to our society. Brazil is considered multiracial due to its colonization, generating important social and regional inequalities. Knowing the costs of the PD may aid to improve local public policies. However, in Brazil, no estimates of these values have been made so far. OBJECTIVES: To evaluate direct, indirect, and out-of-pocket costs in Brazilian people with PD (PwP). METHODS: Categorical and numerical data were collected through a customized and standardized cost-related-questionnaire from 1055 PwP nationwide, from 10 tertiary movement disorders centers across all Brazilian regions. RESULTS: The estimated average annual cost of PwP was US$ 4020.48. Direct and indirect costs accounted for 63% and 36% of the total, respectively, and out-of-pocket costs were 49%. There were no evidence of differences in the total cost of PD across the regions of the country; however, differences were reported between the stages of the Hoehn and Yahr scale (H&Y). CONCLUSION: This data suggests a considerable burden of PD for Brazilian society in general, not only for the public health system, but mainly for those with PD.


Assuntos
Efeitos Psicossociais da Doença , Doença de Parkinson , Humanos , Brasil/epidemiologia , Doença de Parkinson/economia , Inquéritos e Questionários
2.
Brain Sci ; 13(3)2023 Feb 25.
Artigo em Inglês | MEDLINE | ID: mdl-36979211

RESUMO

BACKGROUND: Due to the importance of not mistaking when determining the brain death (BD) diagnostic, reliable confirmatory exams should be performed to enhance its security. This study aims to evaluate the intracranial pressure (ICP) pulse morphology behavior in brain-dead patients through a noninvasive monitoring system. METHODS: A pilot case-control study was conducted in adults that met the BD national protocol criteria. Quantitative parameters from the ICP waveforms, such as the P2/P1 ratio, time-to-peak (TTP) and pulse amplitude (AMP) were extracted and analyzed comparing BD patients and health subjects. RESULTS: Fifteen patients were included, and 6172 waveforms were analyzed. ICP waveforms presented substantial differences amidst BD patients when compared to the control group, especially AMP, which had lower values in patients diagnosed with BD (p < 0.0001) and the TTP median (p < 0.00001), but no significance was found for the P2/P1 ratio (p = 0.8). The area under curve for combination of parameters on the BD prediction was 0.77. CONCLUSIONS: In this exploratory study, noninvasive ICP waveforms have shown potential as a screening method in patients with suspected brain death. Future studies should be carried out in a larger population.

4.
Arq Neuropsiquiatr ; 65(1): 59-62, 2007 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-17420828

RESUMO

OBJECTIVE: To examine auditory cognitive evoked potentials (P300 potentials) and neuropsychological dysfunction in patients with Duchenne muscular dystrophy (DMD). METHOD: P300 potentials and neuropsychological test results were obtained from 16 healthy control boys and 20 DMD patients. Full Intelligence Quotients (IQ) were estimated for patients and control group. Mean age was 9.5 years in the DMD patient group, and 10 years in the control group (p>0.05). RESULTS: The mean IQ values were 64.35 in the DMD patients and 82.68 in the control group (p=0.01). Mean P300 values were 347.6 in the DMD group and 337.4 in the control group (p=0.14). There was no significant correlation between parameters in each group. CONCLUSION: DMD patients showed a poor performance as evaluated by P300 potential compared to the control group, although the difference was not statistically significant. Systematic alterations in neuropsychological test results were found, the differences paralleling those detected in IQ.


Assuntos
Transtornos Cognitivos/fisiopatologia , Potenciais Evocados P300/fisiologia , Potenciais Evocados Auditivos/fisiologia , Distrofia Muscular de Duchenne/fisiopatologia , Adolescente , Estudos de Casos e Controles , Criança , Humanos , Masculino , Testes Neuropsicológicos , Escalas de Wechsler
5.
Arq. neuropsiquiatr ; 65(1): 59-62, mar. 2007. graf, tab
Artigo em Inglês | LILACS | ID: lil-446681

RESUMO

OBJECTIVE: To examine auditory cognitive evoked potentials (P300 potentials) and neuropsychological dysfunction in patients with Duchenne muscular dystrophy (DMD). METHOD: P300 potentials and neuropsychological test results were obtained from 16 healthy control boys and 20 DMD patients. Full Intelligence Quotients (IQ) were estimated for patients and control group. Mean age was 9.5 years in the DMD patient group, and 10 years in the control group (p>0.05). RESULTS: The mean IQ values were 64.35 in the DMD patients and 82.68 in the control group (p=0.01). Mean P300 values were 347.6 in the DMD group and 337.4 in the control group (p=0.14). There was no significant correlation between parameters in each group. CONCLUSION: DMD patients showed a poor performance as evaluated by P300 potential compared to the control group, although the difference was not statistically significant. Systematic alterations in neuropsychological test results were found, the differences paralleling those detected in IQ.


OBJETIVO: Avaliar potenciais evocados cognitivos auditivos (P300) e disfunções neuropsicológicas em pacientes com distrofia muscular de Duchenne (DMD). MÉTODO: Potenciais auditivos P300 e testes neuropsicológicos foram obtidos de 16 controles e 20 pacientes com DMD. Valores de quociente de inteligência (QI) foram estimados para os dois grupos. A media de idade foi de 9.5 anos no grupo DMD e 10 anos no grupo controle (p>0.05). RESULTADOS: Os valores médios de QI foram 64.35 no grupo DMD e 82.68 no grupo controle (p=0.01). A média de valores de P300 foi 347.6 no grupo DMD e 337.4 no grupo controle (p=0.14). Não houve correlação significativa entre os parâmetros em cada grupo. CONCLUSÃO: Os pacientes com DMD mostraram um pior desempenho nas testagens de P300 quando comparados com o grupo controle, embora a diferença não tenha apresentado diferença significativa. Alterações sistemáticas foram encontradas nos testes neuropsicológicos, correspondendo às alterações significativas vistas nos valores de QI.


Assuntos
Adolescente , Criança , Humanos , Masculino , Transtornos Cognitivos/fisiopatologia , /fisiologia , Potenciais Evocados Auditivos/fisiologia , Distrofia Muscular de Duchenne/fisiopatologia , Estudos de Casos e Controles , Testes Neuropsicológicos , Escalas de Wechsler
6.
Arq Neuropsiquiatr ; 61(1): 119-20, 2003 Mar.
Artigo em Português | MEDLINE | ID: mdl-12715034

RESUMO

We report the case of a 30-year-old woman with a 7-year history of distal lower limbs weakness that evolved to upper limbs weakness. On neurological examination, she presented normal cranial nerves, bilateral quadriceps and feet interosseous atrophy, normal muscular tonus, muscular weakness more severe in dorsal feet interosseous and anterior tibial, and decreased deep tendon reflexes. Repetitive nerve stimulation of the ulnar and fibular nerves showed a decrement greater than 10% of the compound muscle action potential. Antibody against acetylcholine receptor titer was positive. Computed tomography scan of the thorax was normal. Thyroid function tests showed evidence of hyperthyroidism. Distal muscular weakness is a rare onset presentation of myasthenia gravis. However, myasthenia gravis must be considered in the differential diagnosis of distal limb weakness.


Assuntos
Debilidade Muscular/etiologia , Miastenia Gravis/complicações , Adulto , Diagnóstico Diferencial , Estimulação Elétrica/métodos , Feminino , Humanos , Perna (Membro) , Contração Muscular , Debilidade Muscular/diagnóstico , Miastenia Gravis/diagnóstico
7.
Arq. neuropsiquiatr ; 61(1): 119-120, mar. 2003. ilus
Artigo em Português | LILACS | ID: lil-331173

RESUMO

Relatamos o caso de uma mulher de 30 anos com quadro de fraqueza muscular nos membros inferiores com predomínio distal com início há 7 anos. Na evoluçäo apresentou fraqueza muscular nos membros superiores. O exame físico mostrava nervos cranianos sem alterações, hipotrofia bilateral de quadriceps e interósseos dos pés, reduçäo da força muscular mais intensa em tibiais anteriores e interósseos dorsais dos pés e reflexos tendinosos globalmente hipoativos. Foi realizado teste de estimulaçäo repetitiva que mostrou decremento maior que 10 por cento no nervo fibular e ulnar. A dosagem de anticorpos anti-receptor de acetilcolina foi positiva. Tomografia computadorizada de tórax foi normal. Dosagem de hormônios tireoidianos mostrou evidências laboratoriais de hipertireoidismo, porém sem manifestações clínicas. Foi iniciado tratamento com piridostigmina havendo melhora importante do quadro clínico. A fraqueza distal é um sintoma inicial raro na miastenia grave (MG). Contudo, a MG deve entrar no diagnóstico diferencial de doenças que cursam com fraqueza muscular distal de membros superiores ou inferiores


Assuntos
Humanos , Feminino , Adulto , Debilidade Muscular , Miastenia Gravis , Diagnóstico Diferencial , Estimulação Elétrica , Perna (Membro) , Contração Muscular , Debilidade Muscular , Miastenia Gravis
8.
Arq. neuropsiquiatr ; 59(3B): 790-792, Sept. 2001. ilus
Artigo em Inglês | LILACS | ID: lil-295850

RESUMO

Autosomal recessive hereditary spastic paraplegia (AR-HSP) associated with thin corpus callosum was recently described in Japan, and most families were linked to chromosome 15q13-15. We report two patients from two different Brazilian families with progressive gait disturbance starting at the second decade of life, spastic paraparesis, and mental deterioration. One patient presented cerebellar ataxia. Magnetic resonance imaging (MRI) of the head of both patients showed a thin corpus callosum. AR-HSP with a thin corpus callosum is a rare disorder, mainly described in Japanese patients. We found only 4 Caucasian families with AR-HSP with thin corpus callosum described in the literature. Further studies including additional Caucasian families of AR-HSP with thin corpus callosum are required to delineate the genetic profile of this syndrome in occidental countries


Assuntos
Humanos , Masculino , Feminino , Adolescente , Corpo Caloso/anormalidades , Paraplegia Espástica Hereditária/genética , Brasil , Corpo Caloso/patologia , População Branca , Imageamento por Ressonância Magnética , Paraplegia Espástica Hereditária/diagnóstico , Paraplegia Espástica Hereditária/patologia
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