[Potential use of indenolol in hypertensive patients with chronic bronchial asthma]. / Possibilità di impiego dell'indenololo negli ipertesi affetti da asma bronchiale cronica.

The data are reported on a double blind clinical experiment using indenolol on a group of asthmatic hypertensives. The drug revealed a satisfactory anti-hypertensive action in the absence of any significantly bronchoconstrictive effect. The orciprenaline test performed at the end of the experiment showed that the drug does not reduce the availability of beta 2 bronchial receptors vis-à-vis the beta 2 stimulants.

[Efficacy of the simultaneous aerosol administration of fenoterol and 2(alpha-thenoylthio)propionylglycine]. / Efficacia della somministrazione aerosolica contemporanea del fenoterolo e della 2(alfa-tenoiltio)propionilglicina.

The aim of the present study was to investigate the effect of a new mucolytic drug 2-alpha-tenoiltium-propionylglycine (2-alpha-TPG) administered in spray form together with a selective beta 2 stimulant, fenoterol. A double blind test was conducted on 26 patients to whom 2-alpha-TPG-fenoterol and placebo-fenoterol were given in spray form in two daily doses for 15 days at 10 day intervals. The data suggest the existence of an additive effect between the mucolytic drug (2-alpha-TPG) and the beta 2 stimulant (fenoterol) that would justify the use of the combination in the treatment of such patients.

[Comparative study of the bronchodilating action of fenoterol and ipratropium bromide administered by aerosols in acute attacks of asthma]. / Raffronto comparativo tra l'attività broncodilatatrice del fenoterolo e dell'ipratropium bromuro somministrati per via aerosolica nell'attacco acuto d'asma.

Eighteen patients hospitalised with acute bronchial asthma are examined. Nine were given aerosol treatment with an ipratropium bromide solution and 45 minutes later with a phenoterol solution. The remaining 9 were given the same treatment in reverse order. The results obtained showed that phenoterol has a stronger bronchodilatory activity than ipratropium bromide, especially when administered after the anticholinergic product.