Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 8 de 8
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Ann Thorac Surg ; 109(5): 1434-1440, 2020 05.
Artigo em Inglês | MEDLINE | ID: mdl-31568745

RESUMO

BACKGROUND: Marfan syndrome predisposes to aortic aneurysm, dissection, and rupture. We sought to investigate aortic 4-dimensional (4D) relative pressure maps derived from 4D flow cardiovascular magnetic resonance to identify disease characteristic alterations of the intraaortic pressure field in Marfan patients with aortic root dilation compared with age- and sex-matched healthy controls. METHODS: This prospective case-control study included 11 Marfan patients with aortic root dilation (31 ± 5 years, 5 female) and 11 age- and sex-matched healthy controls (31 ± 8 years, 5 female) undergoing 4D flow cardiovascular magnetic resonance of the thoracic aorta. 4D relative pressure maps were computed and compared between groups for 8 aortic regions. RESULTS: Aortic root diameters were significantly larger in patients compared with controls (43 vs 31 mm, P < .001), but not in the proximal descending aorta (23 vs 21 mm, P = .19). Regional pressure gradients over the cardiac cycle were significantly altered in Marfan patients with significantly higher minimum pressure gradients in the proximal ascending aorta (-44.3 vs -97.0 mm Hg/m, P < .001) and significantly lower maximum pressure gradients in the proximal descending aorta (55.1 vs 82.3 mm Hg/m, P < .01). The latter finding was associated with pathologic vortical flow patterns. Regional pressure gradient at mid systole significantly correlated with aortic diameter (proximal ascending aorta: r = 0.73, P < .001; proximal descending aorta: r = -0.59, P = .004). CONCLUSIONS: Noninvasive 4D pressure mapping derived from 4D flow cardiovascular magnetic resonance revealed significant alterations of spatiotemporal pressure characteristics in the thoracic aorta of Marfan patients. These alterations were most pronounced in the proximal ascending aorta and the proximal descending aorta, corresponding to the regions where aortic dissections often originate in Marfan patients.


Assuntos
Aorta Torácica/diagnóstico por imagem , Pressão Arterial/fisiologia , Velocidade do Fluxo Sanguíneo/fisiologia , Imageamento Tridimensional/métodos , Imagem Cinética por Ressonância Magnética/métodos , Síndrome de Marfan/fisiopatologia , Adulto , Estudos de Casos e Controles , Feminino , Seguimentos , Humanos , Masculino , Síndrome de Marfan/diagnóstico , Estudos Prospectivos , Reprodutibilidade dos Testes
2.
Int J Cardiovasc Imaging ; 31(4): 823-30, 2015 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-25645544

RESUMO

To assess spatial and temporal pressure characteristics in patients with repaired aortic coarctation compared to young healthy volunteers using time-resolved velocity-encoded three-dimensional phase-contrast magnetic resonance imaging (4D flow MRI) and derived 4D pressure difference maps. After in vitro validation against invasive catheterization as gold standard, 4D flow MRI of the thoracic aorta was performed at 1.5T in 13 consecutive patients after aortic coarctation repair without recoarctation and 13 healthy volunteers. Using in-house developed processing software, 4D pressure difference maps were computed based on the Navier-Stokes equation. Pressure difference amplitudes, maximum slope of pressure amplitudes and spatial pressure range at mid systole were retrospectively measured by three readers, and twice by one reader to assess inter- and intraobserver agreement. In vitro, pressure differences derived from 4D flow MRI showed excellent agreement to invasive catheter measurements. In vivo, pressure difference amplitudes, maximum slope of pressure difference amplitudes and spatial pressure range at mid systole were significantly increased in patients compared to volunteers in the aortic arch, the proximal descending and the distal descending thoracic aorta (p < 0.05). Greatest differences occurred in the proximal descending aorta with values of the three parameters for patients versus volunteers being 19.7 ± 7.5 versus 10.0 ± 2.0 (p < 0.001), 10.9 ± 10.4 versus 1.9 ± 0.4 (p = 0.002), and 8.7 ± 6.3 versus 1.6 ± 0.9 (p < 0.001). Inter- and intraobserver agreements were excellent (p < 0.001). Noninvasive 4D pressure difference mapping derived from 4D flow MRI enables detection of altered intraluminal aortic pressures and showed significant spatial and temporal changes in patients with repaired aortic coarctation.


Assuntos
Aorta Torácica/fisiopatologia , Aorta Torácica/cirurgia , Coartação Aórtica/cirurgia , Pressão Arterial , Determinação da Pressão Arterial/métodos , Procedimentos Cirúrgicos Cardíacos/efeitos adversos , Imageamento por Ressonância Magnética/métodos , Complicações Pós-Operatórias/diagnóstico , Adolescente , Adulto , Coartação Aórtica/diagnóstico , Coartação Aórtica/fisiopatologia , Velocidade do Fluxo Sanguíneo , Cateterismo Periférico , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Modelos Anatômicos , Modelos Cardiovasculares , Variações Dependentes do Observador , Complicações Pós-Operatórias/fisiopatologia , Valor Preditivo dos Testes , Fluxo Sanguíneo Regional , Reprodutibilidade dos Testes , Estudos Retrospectivos , Processamento de Sinais Assistido por Computador , Software , Fatores de Tempo , Resultado do Tratamento , Adulto Jovem
3.
Cardiovasc Diagn Ther ; 4(2): 97-103, 2014 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-24834408

RESUMO

PURPOSE: To develop a method for computing and visualizing pressure differences derived from time-resolved velocity-encoded three-dimensional phase-contrast magnetic resonance imaging (4D flow MRI) and to compare pressure difference maps of patients with unrepaired and repaired aortic coarctation to young healthy volunteers. METHODS: 4D flow MRI data of four patients with aortic coarctation either before or after repair (mean age 17 years, age range 3-28, one female, three males) and four young healthy volunteers without history of cardiovascular disease (mean age 24 years, age range 20-27, one female, three males) was acquired using a 1.5-T clinical MR scanner. Image analysis was performed with in-house developed image processing software. Relative pressures were computed based on the Navier-Stokes equation. RESULTS: A standardized method for intuitive visualization of pressure difference maps was developed and successfully applied to all included patients and volunteers. Young healthy volunteers exhibited smooth and regular distribution of relative pressures in the thoracic aorta at mid systole with very similar distribution in all analyzed volunteers. Patients demonstrated disturbed pressures compared to volunteers. Changes included a pressure drop at the aortic isthmus in all patients, increased relative pressures in the aortic arch in patients with residual narrowing after repair, and increased relative pressures in the descending aorta in a patient after patch aortoplasty. CONCLUSIONS: Pressure difference maps derived from 4D flow MRI can depict alterations of spatial pressure distribution in patients with repaired and unrepaired aortic coarctation. The technique might allow identifying pathophysiological conditions underlying complications after aortic coarctation repair.

4.
Artigo em Inglês | MEDLINE | ID: mdl-24109791

RESUMO

Several approaches for the non-invasive MRI-based measurement of the aortic pressure waveform over the heart cycle have been proposed in the last years. These methods are normally based on time-resolved, two-dimensional phase-contrast sequences with uni-directionally encoded velocities (2D PC-MRI). In contrast, three-dimensional acquisitions with tridirectional velocity encoding (4D PC-MRI) have been shown to be a suitable data source for detailed investigations of blood flow and spatial blood pressure maps. In order to avoid additional MR acquisitions, it would be advantageous if the aortic pressure waveform could also be computed from this particular form of MRI. Therefore, we propose an approach for the computation of the aortic pressure waveform which can be completely performed using 4D PC-MRI. After the application of a segmentation algorithm, the approach automatically computes the aortic pressure waveform without any manual steps. We show that our method agrees well with catheter measurements in an experimental phantom setup and produces physiologically realistic results in three healthy volunteers.


Assuntos
Aorta/fisiologia , Pressão Sanguínea , Meios de Contraste , Imageamento por Ressonância Magnética/métodos , Análise de Ondaletas , Algoritmos , Catéteres , Feminino , Voluntários Saudáveis , Humanos , Masculino , Imagens de Fantasmas , Análise de Onda de Pulso , Adulto Jovem
5.
Int J Cardiovasc Imaging ; 28(8): 1999-2008, 2012 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-22362096

RESUMO

Three-dimensional velocity-encoded cine magnetic resonance imaging (3D VEC MRI) allows for calculation of secondary flow parameters that may be used to estimate prognosis of individual cardiovascular diseases. However, its accuracy has not been fully investigated yet. The purpose of this study was to validate aortic flow quantification by 3D VEC MRI in vitro and in vivo using stacked two-dimensional acquisitions. Time-resolved stacks of two-dimensional planes with three-directional velocity-encoding (stacked-2D-3dir-MRI) were acquired in an elastic tube phantom with pulsatile flow simulating aortic flow as well as in 11 healthy volunteers (23 ± 2 years). Previously validated two-dimensional through-plane VEC MRI at six equidistant levels in vitro and three locations in vivo (ascending aorta/aortic arch/descending aorta) was used as reference standard. The percentage difference of the stacked-2D-3dir-MRI measurement to the reference standard was defined as the parameter for accuracy. For in vitro aortic flow, stacked-2D-3dir-MRI underestimated average velocity by -6.8% (p < 0.001), overestimated average area by 13.6% (p < 0.001), and underestimated average flow by -7.4% (p < 0.001). Accuracy was significantly higher in the field of view centre compared to off-centre (p = 0.001). In vivo, stacked-2D-3dir-MRI underestimated average velocity (all three locations p < 0.001) and overestimated average area at all three locations (p = n.s./<0.001/<0.001). Average flow was significantly underestimated in the ascending aorta (p = 0.035), but tended to be overestimated in the aortic arch and descending aorta. In conclusion, stacked-2D-3dir-MRI tends to overestimate average aortic area and to underestimate average aortic velocity, resulting in significant underestimation of average flow in the ascending aorta.


Assuntos
Aorta/fisiologia , Imageamento Tridimensional , Imagem Cinética por Ressonância Magnética , Adulto , Velocidade do Fluxo Sanguíneo , Elasticidade , Feminino , Humanos , Interpretação de Imagem Assistida por Computador , Imageamento Tridimensional/instrumentação , Imageamento Tridimensional/normas , Imagem Cinética por Ressonância Magnética/instrumentação , Imagem Cinética por Ressonância Magnética/normas , Masculino , Variações Dependentes do Observador , Imagens de Fantasmas , Fluxo Pulsátil , Padrões de Referência , Valores de Referência , Fluxo Sanguíneo Regional , Reprodutibilidade dos Testes , Fatores de Tempo , Adulto Jovem
6.
Acad Radiol ; 19(3): 274-80, 2012 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-22177284

RESUMO

RATIONALE AND OBJECTIVES: Three-dimensional (3D) velocity-encoded cine (VEC) magnetic resonance imaging (MRI) has the potential to quantify 3D hemodynamic aspects known from computational fluid dynamics and to be used to identify hemodynamic risk factors for complications of endovascular aortic repair. The purpose of this study was to investigate the impact of an aortic nickel-titanium (nitinol) stent graft on the accuracy of flow measurements by 3D VEC MRI. MATERIALS AND METHODS: A pump generated pulsatile aortic flow in an elastic tube phantom mimicking the aorta. Stacked two-dimensional three-directional VEC MRI (stacked-2D-3dir-MRI), 3D three-directional VEC MRI (3D-3dir-MRI), and gold-standard 2D through-plane VEC MRI were applied before and after the insertion of an aortic nitinol stent graft. Six equidistant levels were analyzed twice by the same reader. The percentage difference of the measured flow rate from the gold standard was defined as the parameter of accuracy. RESULTS: The overall accuracy of in-stent flow measurements related to the gold standard was -5.4% for stacked-2D-3dir-MRI and -4.1% for 3D-3dir-MRI, demonstrating significant overall underestimation compared to the gold standard (P = .016 and P = .013). However, flow measurements with the stent graft were significantly overestimated by 4.1% using stacked-2D-3dir-MRI (P < .001) and by 5.4% using 3D-3dir-MRI (P = .003) compared to identical measurements without the stent graft. In stacked-2D-3dir-MRI, this positive bias was significantly greater at the proximal and distal ends of the stent graft (P = .025). In 3D-3dir-MRI, measurements along the whole length of the stent graft were affected (P = .006). Intraobserver agreement was excellent, with intraclass correlation coefficients of 0.94 for stacked-2D-3dir-MRI (P < .001) and 0.90 for 3D-3dir-MRI (P < .001). CONCLUSIONS: Flow measurements within an aortic nitinol stent graft by 3D VEC MRI are feasible, but stent grafts may cause a significant positive bias.


Assuntos
Aorta/fisiopatologia , Aorta/cirurgia , Prótese Vascular , Imageamento Tridimensional/métodos , Angiografia por Ressonância Magnética/métodos , Imagem Cinética por Ressonância Magnética/métodos , Stents , Velocidade do Fluxo Sanguíneo , Humanos , Interpretação de Imagem Assistida por Computador/métodos , Angiografia por Ressonância Magnética/instrumentação , Imagem Cinética por Ressonância Magnética/instrumentação , Imagens de Fantasmas
7.
Eur J Radiol ; 80(1): 163-7, 2011 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-20888719

RESUMO

PURPOSE: To validate flow measurements within an aortic nickel-titanium (nitinol) stent graft using velocity-encoded cine magnetic resonance imaging (VEC MRI) and to assess intraobserver agreement of repeated flow measurements. MATERIALS AND METHODS: An elastic tube phantom mimicking the descending aorta was developed with the possibility to insert an aortic nitinol stent graft. Different flow patterns (constant, sinusoidal and pulsatile aortic flow) were applied by a gear pump. A two-dimensional phase-contrast sequence was used to acquire VEC perpendicular cross-sections at six equidistant levels along the phantom. Each acquisition was performed twice with and without stent graft, and each dataset was analysed twice by the same reader. The percental difference of the measured flow volume to the gold standard (pump setting) was defined as the parameter for accuracy. Furthermore, the intraobserver agreement was assessed. RESULTS: Mean accuracy of flow volume measurements was -0.45±1.63% without stent graft and -0.18±1.45% with stent graft. Slightly lower accuracy was obtained for aortic flow both without (-2.31%) and with (-1.29%) stent graft. Accuracy was neither influenced by the measurement position nor by repeated acquisitions. There was significant intraobserver agreement with an intraclass correlation coefficient of 0.87 (without stent graft, p<0.001) and 0.80 (with stent graft, p<0.001). The coefficient of variance was 0.25% without stent graft and 0.28% with stent graft. CONCLUSION: This study demonstrated high accuracy and excellent intraobserver agreement of flow measurements within an aortic nitinol stent graft using VEC MRI. VEC MRI may give new insights into the haemodynamic consequences of endovascular aortic repair.


Assuntos
Ligas , Aorta , Velocidade do Fluxo Sanguíneo , Imagem Cinética por Ressonância Magnética , Imagens de Fantasmas , Stents
8.
Artigo em Inglês | MEDLINE | ID: mdl-22255907

RESUMO

In cardiovascular diagnostics, phase-contrast MRI is a valuable technique for measuring blood flow velocities and computing blood pressure values. Unfortunately, both velocity and pressure data typically suffer from the strong image noise of velocity-encoded MRI. In the past, separate approaches of regularization with physical a-priori knowledge and data representation with continuous functions have been proposed to overcome these drawbacks. In this article, we investigate polynomial regularization as an exemplary specification of combining these two techniques. We perform time-resolved three-dimensional velocity measurements and pressure gradient computations on MRI acquisitions of steady flow in a physical phantom. Results based on the higher quality temporal mean data are used as a reference. Thereby, we investigate the performance of our approach of polynomial regularization, which reduces the root mean squared errors to the reference data by 45% for velocities and 60% for pressure gradients.


Assuntos
Pressão Sanguínea , Imageamento por Ressonância Magnética/métodos , Processamento de Sinais Assistido por Computador , Algoritmos , Velocidade do Fluxo Sanguíneo/fisiologia , Humanos , Processamento de Imagem Assistida por Computador , Imageamento Tridimensional/métodos , Modelos Estatísticos , Modelos Teóricos , Imagens de Fantasmas , Valores de Referência , Reprodutibilidade dos Testes , Fatores de Tempo
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...