1.
Ann Pediatr (Paris)
; 34(9): 713-7, 1987 Nov.
Artigo
em Francês
| MEDLINE
| ID: mdl-3426082
Assuntos
Fibrose Cística/metabolismo , Dibecacina/sangue , Canamicina/análogos & derivados , Adolescente , Infecções Bacterianas/tratamento farmacológico , Criança , Pré-Escolar , Fibrose Cística/sangue , Fibrose Cística/complicações , Dibecacina/farmacocinética , Feminino , Humanos , Masculino , Ticarcilina/sangue , Ticarcilina/farmacocinética
2.
Int J Clin Pharmacol Res
; 5(2): 87-91, 1985.
Artigo
em Inglês
| MEDLINE
| ID: mdl-4018945
RESUMO
Dosages and pharmacokinetics of dibekacin were studied in a group of 15 children with cystic fibrosis (CF) and a control group of 9 children. The mean dosage regimens of dibekacin were respectively equal to 2.19 mg/kg and 2.16 mg/kg in the CF and non-CF patients. The mean peak serum values for the CF and non-CF groups were respectively equal to 5.3 micrograms/ml. Comparison of pharmacokinetic parameters (i.e. half-life, distribution volume, total body clearance and area under the curve) showed no significant difference between the two groups (p greater than 0.05).
