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1.
Eur J Pediatr ; 173(1): 25-32, 2014 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-24146165

RESUMO

The prevalence of obesity has exponentially risen worldwide. The etiology of obesity is multifactorial, and genetic inheritance and behavioral/environmental causes are considered the main etiological factors. Moreover, evidence that specific infections might promote the development of obesity has steadily accumulated. Only a few works investigate the impact of obesity on the immune response to infections and the risk of infections in the obese population. The aim of this paper was to review the available data regarding the various aspects of the association between obesity and infections and to highlight the possibility that infectious agents may have an etiological role in obesity, an idea known as "infectobesity". Several microbes have been considered as possible promoter of obesity, but most of the data concern adenovirus-36 that exerts an adipogenic action mainly via a direct effect on adipose tissue leading to weight gain, at least in animal models.Obesity affects the immune response leading to an increased susceptibility to infections. Obese adults and children show an increased incidence of both nosocomial and community-acquired infections. Furthermore, obesity may alter the pharmacokinetics of antimicrobial drugs and impact on vaccine response. However, the various aspects of the association of obesity infections remain poorly studied, and a call to research is necessary to better investigate the problem.In conclusion, obesity impacts millions globally, and greater understanding of its etiology and its effects on immunity, infections, and prevention and management strategies is a key public health concern.


Assuntos
Infecções Comunitárias Adquiridas/complicações , Infecção Hospitalar/complicações , Obesidade/etiologia , Infecções por Adenoviridae/complicações , Infecções por Adenoviridae/imunologia , Tecido Adiposo/fisiopatologia , Adulto , Criança , Humanos , Obesidade/fisiopatologia , Fatores de Risco
2.
Epilepsia ; 51(2): 312-5, 2010 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-19780793

RESUMO

A relationship between ghrelin and epilepsy has been already shown in humans, although the results are controversial. Ghrelin levels are reduced in obesity. Epileptic patients progressively develop a therapy-linked weight gain; however, the mechanisms for this have not been fully explained. The aim of our study is to evaluate if ghrelin secretion is modulated by treatment with carbamazepine or valproic acid in young prepubertal epileptic children. Ghrelin levels were reduced in normal-weight young epileptic prepubertal children under treatment with carbamazepine (p < 0.0001) or valproic acid (p < 0.006) compared to healthy age- and weight-matched subjects. Ghrelin was also lower in children under carbamazepine when compared to those under valproic acid (p < 0.01). A derangement in ghrelin secretion in epilepsy during specific pharmacologic therapies and independent of weight gain could be hypothesized.


Assuntos
Carbamazepina/uso terapêutico , Epilepsia/tratamento farmacológico , Grelina/sangue , Ácido Valproico/uso terapêutico , Fatores Etários , Anticonvulsivantes/efeitos adversos , Anticonvulsivantes/sangue , Anticonvulsivantes/uso terapêutico , Estatura/fisiologia , Índice de Massa Corporal , Carbamazepina/efeitos adversos , Carbamazepina/sangue , Criança , Depressão Química , Epilepsia/sangue , Feminino , Grelina/efeitos dos fármacos , Humanos , Masculino , Puberdade/sangue , Estatísticas não Paramétricas , Ácido Valproico/efeitos adversos , Ácido Valproico/sangue , Aumento de Peso/fisiologia
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