1.
Bioorg Med Chem Lett
; 10(15): 1695-9, 2000 Aug 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10937727
RESUMO
A new series of coumarin inhibitors of DNA gyrase B bearing a N-propargyloxycarbamate at C-3' of various 5',5'-dialkylnoviose, including RU79115, were synthesised and their antibacterial activities have been delineated. Introduction of dialkyl substituents at 5'5'-position of noviose leads to coumarin analogues with improved in vitro and in vivo antibacterial activity.