Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
BMC Infect Dis ; 24(1): 536, 2024 May 28.
Artigo em Inglês | MEDLINE | ID: mdl-38807049

RESUMO

BACKGROUND: The aim of this study was to assess the impact of immunosuppression management on coronavirus disease 2019 (COVID-19) outcomes. METHODS: We performed a single-center retrospective study in a cohort of 358 lung transplant recipients (LTx) over the period from March 2020 to April 2022. All included symptomatic patients had at least one positive SARS-CoV-2 rt-PCR. We used a composite primary outcome for COVID-19 including increased need for oxygen since the hospital admission, ICU transfer, and in-hospital mortality. We assessed by univariate and multivariate analyses the risk factors for poor outcomes. RESULTS: Overall, we included 91 LTx who contracted COVID-19. The COVID-19 in-hospital mortality rate reached 4.4%. By hierarchical clustering, we found a strong and independent association between the composite poor outcome and the discontinuation of at least one immunosuppressive molecule among tacrolimus, cyclosporine, mycophenolate mofetil, and everolimus. Obesity (OR = 16, 95%CI (1.96; 167), p = 0.01) and chronic renal failure (OR = 4.6, 95%CI (1.4; 18), p = 0.01) were also independently associated with the composite poor outcome. Conversely, full vaccination was protective (OR = 0.23, 95%CI (0.046; 0.89), p = 0.047). CONCLUSION: The administration of immunosuppressive drugs such as tacrolimus, cyclocporine or everolimus can have a protective effect in LTx with COVID-19, probably related to their intrinsic antiviral capacity.


Assuntos
COVID-19 , Imunossupressores , Transplante de Pulmão , SARS-CoV-2 , Transplantados , Humanos , COVID-19/mortalidade , Masculino , Feminino , Estudos Retrospectivos , Pessoa de Meia-Idade , Transplante de Pulmão/efeitos adversos , Transplante de Pulmão/mortalidade , Imunossupressores/uso terapêutico , Transplantados/estatística & dados numéricos , Idoso , SARS-CoV-2/imunologia , Terapia de Imunossupressão , Adulto , Fatores de Risco , Mortalidade Hospitalar , Tacrolimo/uso terapêutico
2.
Med Mycol ; 48 Suppl 1: S32-6, 2010 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-21067327

RESUMO

A total of 657 sputum samples from 201 cystic fibrosis adult patients were collected during a 24-month period (2005-2006). We retrospectively analyzed the fungal colonization of the respiratory tract of these individuals by linking medical records and microbiological data. Filamentous fungi were isolated from specimens of 65.6% of the patients, with Aspergillus fumigatus being the predominant species recovered as it was found in specimens of 56.7% of the patients. We observed no difference for gender, pancreatic status and cirrhosis in patients with or without A. fumigatus colonization. We found a higher percentage of recovery of Pseudomonas aeruginosa, Stenotrophomonas maltophilia and nontuberculous mycobacteria in patients with A. fumigatus colonization. During the follow-up period of the study, 8.9% of the patients were diagnosed with allergic bronchopulmonary aspergillosis (ABPA). By a multivariate analysis we demonstrated that Scedosporium apiospermum was significantly associated with ABPA (Odds ratio = 13 [2-80]) as opposed to A. fumigatus (Odds ratio = 1.58 [0.49-5.05]).


Assuntos
Fibrose Cística/complicações , Fungos/isolamento & purificação , Pneumopatias Fúngicas/epidemiologia , Pneumopatias Fúngicas/fisiopatologia , Escarro/microbiologia , Adolescente , Adulto , Idoso , Aspergilose Broncopulmonar Alérgica/epidemiologia , Aspergilose Broncopulmonar Alérgica/microbiologia , Aspergillus fumigatus/classificação , Aspergillus fumigatus/isolamento & purificação , Fibrose Cística/epidemiologia , Fibrose Cística/microbiologia , Feminino , França/epidemiologia , Humanos , Pneumopatias Fúngicas/microbiologia , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Scedosporium/classificação , Scedosporium/isolamento & purificação , Adulto Jovem
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...