RESUMO
52 infertile women (age range 19-35 years) treated by Gynatren-immunopotentialization (three vaccinations every second week) were divided into two groups according to appearance of cervical intraepithelial neoplasia (CIN). 30 women had CIN cytologically diagnosed and proved by colposcopy (group II). Colposcopic examinations were performed on the first day of therapy (first vaccination), after two weeks (second vaccination) and after four weeks (the day of the third injection). Four weeks of the therapy resulted in normalization of cervical milieu (e.g., complete regression of infection in 68.2% of I group and 56% of II group) as well as in disappearance of CIN in 66% of cases and in remaining ones there was a 7-times decrease of CIN II. It was colposcopically stated that the process of statistical significant regression of inflammation as well as normalization of cervical pathology is less apparent in women with CIN. These findings confirmed our previous cytological observations.
Assuntos
Adjuvantes Imunológicos/uso terapêutico , Vacinas Bacterianas/uso terapêutico , Colposcopia , Displasia do Colo do Útero/tratamento farmacológico , Adjuvantes Imunológicos/administração & dosagem , Adjuvantes Imunológicos/farmacologia , Adulto , Vacinas Bacterianas/administração & dosagem , Vacinas Bacterianas/farmacologia , Feminino , Humanos , Displasia do Colo do Útero/diagnóstico , Displasia do Colo do Útero/imunologiaRESUMO
Sixty one women (age range 20-35 years) treated by Gynatren-immunopotentialization (three vaccinations every second week) were divided into two groups: group I with cervical intraepithelial neoplasia (CIN) and group II without CIN. Four weeks of therapy resulted in normalization of the vaginal flora and cervical milieu as well as in disappearance of CIN in 54% of cases stated cytologically. These findings confirmed our previous observations. Moreover, it was stated that process of regression of inflammation, metaplasia as well as normalization of vaginal flora is less apparent in women with CIN.
Assuntos
Vacinas Bacterianas/imunologia , Neoplasias/terapia , Adulto , Feminino , Humanos , Imunoterapia , Infertilidade Feminina , Doenças do Colo do Útero , Vacinação , Vacinas Sintéticas , Esfregaço VaginalAssuntos
Ovulação , Esfregaço Vaginal , Feminino , Humanos , Monitorização Fisiológica , Detecção da Ovulação , UltrassonografiaRESUMO
The injection of viable rat spleen cells beneath the renal capsule of cyclophosphamide (CY)-treated adult mice produced a localized graft versus host reaction (GvHR), manifested by the kidney enlargement index (KI). The optimal xenogeneic GvHR was obtained after injection of 30-50 million rat spleen cells into mouse recipients treated 24 hr before with CY, 200 mg/kg intraperitoneally (i.p.), and killed 7 days later. Splenomegaly in recipient mice suggested systemic dissemination of the local GvHR.
