RESUMO
The aim was to investigate compare genotype and allele frequencies of the GPX1 gene Pro198Leu polymorphism in 736 Russian athletes and 564 non-athletic controls. Echocardiography was performed by ultrasound scanner Nemio MX (Toshiba, Japan). Also, we investigated whether glutathione had antioxidant effects in runners. Runners of the experimental group 1 (16 persons) unlike the group 2 (16 persons) had been administered 600 mg of glutathione sodium intramuscularly after trainings daily, during 14 days. The best response to glutathione was presented by the GPX1 Pro allele.
Assuntos
Antioxidantes/administração & dosagem , Atletas , Glutationa Peroxidase/genética , Glutationa/administração & dosagem , Consumo de Oxigênio/genética , Adulto , Alelos , Estudos de Casos e Controles , Feminino , Expressão Gênica , Frequência do Gene , Genótipo , Heterozigoto , Homozigoto , Humanos , Injeções Intramusculares , Leucina/genética , Masculino , Resistência Física/fisiologia , Polimorfismo de Nucleotídeo Único , Prolina/genética , Glutationa Peroxidase GPX1RESUMO
We studied the relationship between G197A polymorphism of IL-17A gene and changes in morphometric echocardiography parameters and physiological parameters in skiers (19 examinees). Genotyping was performed by restriction fragment length polymorphism analysis and echocardiography using a Nemio MX ultrasound scanner (Toshiba). Association of 197A allele of IL-17A gene with low myocardial growth and high aerobic performance of athletes was demonstrated.
Assuntos
Exercício Físico , Coração/anatomia & histologia , Interleucina-17/genética , Polimorfismo Genético , Esportes , Adolescente , Adulto , Feminino , Coração/fisiologia , Humanos , Masculino , Adulto JovemRESUMO
The aim of this study was to evaluate the effects of short-term creatine supplementation on exercise performance in male athletes depending on the studied genotypes. The present study was limited as long as to two common polymorphisms, such as C34T AMPD1 and Pro12Ala PPARG, selected because previously reported these associations with various aspects of metabolic abnormalities. Athletes had significantly higher frequency of T allele compared to controls AMPD1 34T (7.9 vs. 15.6 %, p < 0.0001) and PPARG 12Ala allele compared to controls (20.7 vs. 15.8%, p < 0.0001). During the experimental period, 21 football players were randomly assigned to either creatine (n = 11) or a dextrose (placebo) (n = 10) supplementation groups. The best response to creatine was presented by AMPD1 CC genotype. Increases in relative VO2(max) values were a significantly (p = 0.052) higher in AMPD1 CT genotype carriers (n = 3; 2.94 ± 0.59 mL x kg(-1) x min(-1)) than AMPD1 CC genotype carriers (n = 8; 0.03 ± 0.01 mL x kg(-1) x min(-1)). We found decrease blood lactate accumulation (La(max)) in AMPD1 CT genotype by 0.84 ± 0.05 mmol x L(-1), and increase by 0.63 ± 0.17 mmol x L(-1) (p = 0.034) in AMPD1 CC genotype.
Assuntos
AMP Desaminase/genética , Creatina/administração & dosagem , Suplementos Nutricionais , PPAR gama/genética , Resistência Física/efeitos dos fármacos , Esforço Físico/efeitos dos fármacos , Adolescente , Alelos , Atletas , Expressão Gênica , Frequência do Gene , Genótipo , Humanos , Masculino , Resistência Física/genética , Esforço Físico/genética , Polimorfismo de Nucleotídeo Único , Futebol , Capacidade Vital/efeitos dos fármacos , Adulto JovemRESUMO
The aim of the was to investigate the interrelation between MTHFR gene C677T polymorphism and morphometric echocardiography and physiologic parameters in male ski racers (n = 23). Genotyping was performed by RFLP. Echocardiography was performed by ultrasound scanner Nemio MX (Toshiba, Japan). We found that the MTHFR C677 allele was associated with low myocardial growth and high physical performance of athletes.
