[Erythropoietin in differential diagnosis of erythremia and secondary erythrocytosis]. / Eritropoétin v differentsial'noi diagnostike éritremii i vtorichnykh éritrotsitozov.

The results of estimating blood plasma erythropoietic activity in patients with polycythemia of unclear genesis, in 95% of cases coincided with the clinical diagnosis proved during further follow up. These data have permitted recommendation of estimating blood plasma erythropoietic activity in patients to verify the diagnosis of polycythemic states.

[Streptodecase-2 in the treatment of acute myocardial infarct, unstable stenocardia, thromboembolism and thrombosis]. / Streptodekaza-2 pri lechenii ostrogo infarkta miokarda, nestabil'noi stenokardii, tromboémbolii i trombozov.

Eleven patients underwent thrombolytic therapy with streptodekase-1 and 19 with streptodekase-2. Of these, 11 patients suffered acute myocardial infarction, 10 had unstable angina pectoris, 6 thromboembolism of the pulmonary artery, 2 thromboembolism of the peripheral arteries and 1 thrombosis of the femoral vein. Administration of streptodekase-2 brought about an increase of the total blood fibrinolytic activity (the fibrinolysis time dropped from 248.8 +/- 82.1 to 137.5 +/- 42.5 min after 12 h), plasmin activation (from 0.00 +/- 0.00 to 23.5 +/- 7.5 mg after 24 h), reduction of the plasminogen content (from 94.0 +/- 2.5 to 46.8 +/- 5.3% after 12 h). The parameters of the coagulation hemostasis did not undergo any appreciable changes. Fibrinolysis activation following streptodekase-2 administration was unchanged within the first 48 hours. No material differences were identified in fibrinolysis activation in patients given streptodekase-2 and streptodekase-1. Administration of streptodekase-2 was found to exert a marked beneficial clinical effect on acute myocardial infarction, unstable angina pectoris, thromboembolism of the pulmonary and peripheral arteries.

[Cytomegalovirus disease (a description of 2 cases and a review of the literature)]. / Tsitomegalovirusnaia bolezn' (opisanie dvukh sluchaev i obzor literatury).

The paper is concerned with general information on this infection with the description of 2 cases. In one of the patients the disease developed suddenly. There was no reason to suppose SAID, an immunosuppressive state of another genesis. A course of disease was very grave with the involvement of many organs and systems, the bone marrow. The hematological picture of disease was of particular interest (infection carriers--atypical mononuclears were detected in the blood). Diagnosis was made only at autopsy. This case was illustrative in view of usual search for bacterial infection in patients with fever and physicians' insufficient knowledge of this infection. In the second patient suffering from CML cytomegaloviral disease was diagnosed during her life-time. Causes of the fever syndrome (whether it was due to tumor progression or infection) were analyzed. The former seemed more probable.

[Secondary erythrocytoses]. / Vtorichnye eritrotsitozy.

The author provides data pertinent to the modern classification of erythrocytosis, which rests on the pathogenetic principle. The difference in the pathogenesis of erythremia and secondary erythrocytoses was proved with the help of an erythroid culture and by examination of erythropoietins, which can be thus used for diagnostic purposes. Analysis of so-called "pure" erythrocytosis has shown that this term implies different patterns of erythrocytosis from the standpoint of the pathogenesis: erythremia, secondary erythrocytoses that are difficult to diagnose, and hereditary erythrocytosis associated with erythropoietin hyperproduction. There is no evidence for the existence of the "pure" erythroid leukemia and thus the author doubts this disease entity. Analysing the different patterns of secondary absolute erythrocytosis the author discusses specific problems of their pathogenesis. Attention is paid to erythrocytosis of a tobacco smoker, to the role of obesity and concomitant action of some factors on the development of hypoxic erythrocytosis. The data are presented on the new types of erythrocytosis, on the post-transplantation one, in particular, which occurs after kidney transplantation, and finally on erythrocytosis that develops occasionally in patients on hemodialysis. Attention is paid as well to relative erythrocytoses, risk factor in the development of thrombotic complications. The problems of etiologically and pathogenetically valid therapy of secondary erythrocytoses are reviewed.

[Intensive therapy during splenectomy in patients with subleukemic myelosis]. / Intensivnaia terapiia pri splenéktomii u bol'nykh subleikemicheskim mielozom.

On the basis of analysis of splenectomies in 25 patients in the terminal stage of subleukemic myelosis--myelofibrosis with the aim of prevention and treatment of complications and better endurability of splenectomy the authors have elaborated a complex of measures for intensive therapy such as conducting the operation under protection of donor thrombocytes, limited transfusion of the whole blood, early administration of antibiotics, heparin therapy and disaggregation therapy in postoperative therapy.