RESUMO
The 53 patients with chronic renocardiac syndrome, with hypertension in chronic kidney disease, were investigated. In the presence of chronic renal failure there is a decrease of cholesterol in the membrane, which is the basis for the violation liquid characteristics of cell membranes. Changes in the exchange of phospholipids and an increase in the exchange rate reflect increasing phosphatidylcholine lipid peroxidation, increasing in chronic renal failure. The degradation of cell membranes reflects a compensatory accumulation in these fractions of phosphatidylcholine, a major component of the outer layer of biomembranes. Regardless of the degree of renal dysfunction and clinical manifestations of the disease in the membranes of platelets accumulate lizoform phospholipids, indicating a strengthening of the processes of lipid peroxidation and accumulation of biologically active substances, which have membrane-destructive activity.
Assuntos
Síndrome Cardiorrenal/sangue , Membrana Eritrocítica/química , Hipertensão/sangue , Adolescente , Adulto , Transporte Biológico , Síndrome Cardiorrenal/patologia , Estudos de Casos e Controles , Colesterol/análise , Colesterol/metabolismo , Doença Crônica , Membrana Eritrocítica/patologia , Ácidos Graxos não Esterificados/análise , Ácidos Graxos não Esterificados/metabolismo , Feminino , Humanos , Hipertensão/patologia , Peroxidação de Lipídeos , Masculino , Fluidez de Membrana , Pessoa de Meia-Idade , Fosfolipídeos/análise , Fosfolipídeos/metabolismo , Triglicerídeos/análise , Triglicerídeos/metabolismoRESUMO
Left ventricular diastolic dysfunction in patients with diabetes is formed in the absence of atherosclerotic changes as a consequence of diabetic cardiac autonomic neuropathy in the early stages of diabetes. Progression of autonomic cardiac neuropathy in cardio-vascular type is associated with the violation of energy supply of cells, protein synthesis, electrolyte exchange, the exchange of trace elements, oxidation reduction processes, oxygen-transport function of blood, so that metabolic therapy is carried out to optimize the processes of formation and energy costs. The drug cocarnit activates processes of aerobic oxidation of glucose, as well as providing regulatory influence on the oxidation of fatty acids. Applying of cocarnit in complex therapy in patients with diabetic cardiac autonomic neuropathy found improvement of left ventricular diastolic function, and positive dynamics in the efferent activity balance of the sympathetic and parasympathetic control of heart rate variability, which provides the regression of clinical symptoms.
Assuntos
Cardiomiopatias/tratamento farmacológico , Cardiotônicos/uso terapêutico , Diabetes Mellitus Tipo 2/tratamento farmacológico , Neuropatias Diabéticas/tratamento farmacológico , Disfunção Ventricular Esquerda/tratamento farmacológico , Trifosfato de Adenosina/farmacologia , Trifosfato de Adenosina/uso terapêutico , Adolescente , Adulto , Sistema Nervoso Autônomo/efeitos dos fármacos , Sistema Nervoso Autônomo/metabolismo , Cardiomiopatias/complicações , Cardiomiopatias/metabolismo , Cardiotônicos/farmacologia , Diabetes Mellitus Tipo 2/complicações , Diabetes Mellitus Tipo 2/metabolismo , Neuropatias Diabéticas/complicações , Neuropatias Diabéticas/metabolismo , Combinação de Medicamentos , Ácidos Graxos/metabolismo , Feminino , Glucose/metabolismo , Coração/efeitos dos fármacos , Frequência Cardíaca/efeitos dos fármacos , Humanos , Masculino , Pessoa de Meia-Idade , Niacinamida/farmacologia , Niacinamida/uso terapêutico , Oxirredução , Tiamina Pirofosfato/farmacologia , Tiamina Pirofosfato/uso terapêutico , Disfunção Ventricular Esquerda/complicações , Disfunção Ventricular Esquerda/metabolismo , Função Ventricular Esquerda/efeitos dos fármacos , Função Ventricular Esquerda/fisiologia , Vitamina B 12/farmacologia , Vitamina B 12/uso terapêuticoRESUMO
The paper was conducted sonographic study of extracranial atherosclerotic vascular changes in patients with diabetes mellitus, and lipid profile study of the dynamics under the influence of treatment with the inclusion of the drug "Reytoil". Structural changes of the vascular wall correlates with changes of lipid profile in patients with diabetes. Structural assessment of intima-media complex (IMC) can be used as a marker for early diagnosis of vascular remodeling in patients with diabetes, as well as the criterion of efficiency of a treatment. Detection of lipid exchange and evaluation of IMC in the early stages of diabetes mellitus will make it possible pathogenetic approach to providing comprehensive treatment of diabetes with dyslipidemia, including the drug "Reytoil".