RESUMO
Tributyl phosphate (TBP) enhances 238Pu penetration at all stages of its transport in the organism, significantly influences the rates and levels of its cumulation and elimination, the duration of its deposition in organs and tissues. The detected differences indicate the necessity to take them into account in the assessment of danger of exposure to 238Pu in combination with TBP.
Assuntos
Organofosfatos/farmacocinética , Plutônio/farmacocinética , Protetores contra Radiação/farmacocinética , Administração por Inalação , Animais , Feminino , Organofosfatos/administração & dosagem , Plutônio/administração & dosagem , Protetores contra Radiação/administração & dosagem , Ratos , Ratos Endogâmicos , Distribuição TecidualRESUMO
Tributyl phosphate intratracheally administered to rat body with a Pu(IV)-TBP complex does not increase the accumulation of plutonium in the skeleton and liver. Plutonium is excreted from the lungs more readily than Pu(IV) nitrate and its large amounts are resorbed in the blood early after the administration; its excretion in feces is approximately 100 times more intense than in urine.