RESUMO
BACKGROUND/AIMS: H. pylori-induced hyperproliferation of the gastric epithelium may have a critical role in gastric carcinogenesis. H. pylori-related hyperproliferation and reversibility of hyperproliferation after eradication therapy is still controversial. Therefore, we have evaluated the effects of H. pylori and its eradication on gastric antral epithelial proliferation. METHODOLOGY: A total of 32 H. pylori-positive and 22 H. pylori-negative subjects were enrolled into the study. Triple eradication therapy was given to the H. pylori-positive group. Upper endoscopy was repeated one month after the therapy and six months later, antral biopsy specimens were taken in each endoscopy. Biopsy specimens from H. pylori-negative subject were taken at the beginning of the study and sixth months later also. RESULTS: Proliferative index was 40.2% in H. pylori-positive state; it regressed to 27.6% after eradication and six months later the proliferative index was 30.7%. H. pylori-negative group's proliferative index was 25.5% initially and six months later it was 25.6%. The difference between the H. pylori-positive and -negative group was statistically significant (p<0.0001). The difference between H. pylori-positive group's values at the beginning of the study and one month after the eradication was significant (p<0.0001). In addition, the difference between H. pylori-positive group's initial values and those six months after eradication was also significant (p<0.0001). CONCLUSIONS: H. pylori increased the gastric epithelial proliferation and after the eradication therapy proliferative index decreased to control values. H. pylori and the related factors inducing gastric antral hyperproliferation may have an important role in H. pylori-related gastric malignancies.
Assuntos
Amoxicilina/uso terapêutico , Antibacterianos/uso terapêutico , Antiulcerosos/uso terapêutico , Divisão Celular/efeitos dos fármacos , Transformação Celular Neoplásica/efeitos dos fármacos , Claritromicina/uso terapêutico , Mucosa Gástrica/efeitos dos fármacos , Gastrite/tratamento farmacológico , Infecções por Helicobacter/tratamento farmacológico , Helicobacter pylori/efeitos dos fármacos , Omeprazol/análogos & derivados , Omeprazol/uso terapêutico , Neoplasias Gástricas/prevenção & controle , 2-Piridinilmetilsulfinilbenzimidazóis , Adulto , Biópsia , Transformação Celular Neoplásica/patologia , Quimioterapia Combinada , Epitélio/efeitos dos fármacos , Epitélio/patologia , Feminino , Seguimentos , Mucosa Gástrica/patologia , Gastrite/patologia , Gastroscopia , Infecções por Helicobacter/patologia , Helicobacter pylori/patogenicidade , Humanos , Lansoprazol , Masculino , Pessoa de Meia-Idade , Antro Pilórico/efeitos dos fármacos , Antro Pilórico/patologia , Neoplasias Gástricas/patologia , Virulência/efeitos dos fármacosRESUMO
There are two main Nuclear Medicine techniques, the gastroesophageal reflux scintigraphy with late lung imaging and the nuclear salivagram, for diagnosis of pulmonary aspiration. Each of the techniques can document the two different, antegrade and retrograde, routes of pulmonary aspiration. In this report, we presented a patient with recurrent respiratory problems and emphasized the importance of concomitant use of the two techniques in the radionuclide diagnosis of aspiration.
