[Analysis of immunological indices of occupational sensibilization to tylosin]. / Analiz immunologicheskikh pokazatelei professional'noi sensibilizatsii k tilozinu.

The authors studied sensibilization to antibiotic Tilosine and determined several immunologic parameters in Tilosine production workers, searching for criteria of the sensibilization's occupational etiology. The results prove that skin allergic reactivity, antibodies production and lymphocytes proliferation response are diagnostic for immune changes in workers exposed to occupational allergens and useful for assessing risk of allergic disorders.

[Occupational sensitization to methylene diphenyl diisocyanate during the manufacture of polyurethane products]. / Profesionalna senzibilizatsiia s metilen-difenil-diizotsianat v proizvodstvoto na poliuretanovi izdeliia.

A complex occupational hygienic and clinical allergologic investigation in a methylene-diphenyl diizocyanate (MDI)-based polyurethane products manufacture was carried out for the first time in this country. The average MDI concentrations for a shift are within the limits of TWA, but during short operations exceed STEL and reach 0.072-0.181 mg/m3. By clinical and immuno-allergologic methods, applied on 46 MDI-exposed workers and 42 controls, the sensibilizing effect on the respiratory system, skin and eyes was detected. The allergic reactions take the course of bronchial asthma (6.5%), rhinitis and rhinopharyngitis (37%), rhinosinusitis (13%), conjunctivitis (13%), and urticaria and dermatitis (17.4%), as in 12 cases (12%) the allergic illnesses are combined. The specific occupational sensibilization, proved by positive dermal allergy tests with MDI in 24 (52%) exposed workers, and increased MDI-IgE antibodies in 4 workers, is of high statistical reliability in comparison with the control group and supposes immune reactions of quick type (IgE) and mainly retarded type--cell mediated. Various prophylactic measures against the proven occupational sensibilization risk are proposed.

[Clinico-allergological studies of workers in the manufacture of fodder yeasts]. / Kliniko-alergologichni izsledvaniia na rabotnitsi ot proizvodstvoto na furazhni drozhdi.

The authors have examined 161 persons from the production of fodder yeasts. On the background of detailed clinical examination are performed immunoallergological studies, including skin allergologic tests with series of standard allergens and antigens of the produced culture yeasts and determined immunoprecipitants in the blood serum. Increased sensibilization is established in 34.7% of the examined, as the prevailing cases are with monoallergy. More seldom--in 18.8% are established immunoprecipitations with the professional allergens. The changed general and specific immunoallergologic reactivity in part of the workers is due exclusively to the biological factors of the working environment.