Incidence and predictors of loss to follow-up among Ethiopian children on antiretroviral therapy: a systematic review and meta-analysis.

INTRODUCTION: Loss of follow-up (LTFU) from ART regular follow-up is one of the key acknowledged causes for the development of ART-resistant virus strains currently. It becomes a major weakness for the successful implementation of HIV care and treatment programs mainly in Sub-Saharan Africa but also globally. About 20-40% of children on ART loss their regular ART follow-up annually. Because of the inconsistency of the prior publications' findings, policymakers, programmers, and healthcare providers find it difficult to intervene. Hence, this study was conducted to provide a pooled incidence and identify the predictors of LTFU among children on ART in Ethiopia. METHODS: Articles were searched from PubMed/ MEDLINE, CINAHL, EMBASE, Google Scholar, and Science Direct, as well as organizational records and websites. This review included both retrospective and prospective follow-up studies published in English. The data were extracted using Microsoft Excel and exported into Stata™ Version 17.0 for further processing and analysis. The presence of heterogeneity was assessed using forest plots with the I2 test. To identify the source of heterogeneity subgroup analysis, meta-regression, publication bias, and sensitivity analysis were computed. The pooled incidence of LTFU was estimated using a random effects meta-analysis model with the DerSimonian-laired method. To identify the predictors, a 95% confidence interval with relative risk was used to declare the presence or absence of an association. RESULTS: In this systematic review and Meta-analysis, nine studies with a total of 3336 children were included. The pooled incidence of LTFU from ART was 5.83 (95% CI: 3.94, 7.72) per 100 children-years of observation with I2: 83% & p-value < 0.001. Those children who were from rural were had a 1.65 (95% CI: 1.06, 2.52) times higher chance of getting LTFU when compared with their counterparts. Children who had poor ART adherence had a 2.03 (95% CI: 1.23, 3.34) times higher chance of experiencing LTFU of ART than children having good ART adherence. CONCLUSIONS: Among Ethiopian children on ART, one out of 167 had the risk of experiencing LTFU. Being rural dwellers and having poor ART adherence were the identified predictors of LTFU. Close follow-up and phone message text should be used to have good ART adherence among rural dwellers to meet the predetermined goal of ART.

Utilization of modern contraceptives and associated factors among street women in Dire Dawa, Eastern Ethiopia: a mixed study.

INTRODUCTION: Unwanted pregnancy and sexually transmitted diseases are the major problems in street women because of the non-utilization of modern contraceptives. To the best of our knowledge, no studies have assessed the utilization of modern contraceptives and associated factors among street women in the study area. Therefore, this study aimed to determine the utilization of modern contraceptives and its associated factors among street women. METHODS: A community-based cross-sectional study using mixed methods was conducted from February 16th to April 10, 2021, among all censuses and 615 reproductive-aged street women. Face-to-face and in-depth interviews were employed to generate quantitative and qualitative data, respectively. Binary logistic regression was used to analyze the association between modern contraceptive utilization and independent variables with statistical significance set at p < 0.05. Qualitative data were analyzed using a thematic approach. RESULTS: Approximately half 279 (50.3%) (95% CI: 46.3%, 54.4%) street women currently used modern contraceptives. Factors significantly associated were women aged 25-34 years [AOR = 5.5, 95% CI: 1.2-24], distance from a nearby health facility within 30 min [AOR = 9.2, 95% CI: 1.6-51], getting advice from health professionals [AOR = 14.3; 95% CI = 5.3-38.4], discussed with their sexual partners about the utilization of modern contraceptives [AOR = 6.2, 95% CI: 2.4-16.5], a history of pregnancy [AOR = 2.7, 95% CI: 1.2-6], the desire to have a child after two years [AOR = 2.2, 95% CI: 1.1-4.7], and women who faced rape in street life [AOR = 5.4; 95% CI = 1.9-15.3]. Fear of side effects, misperceptions, and the desire to have a child are the main identified themes for the key barriers to using modern contraceptives. CONCLUSION: The proportion of street women currently using modern contraceptives was low. Age, distance from the health facility, discussion with health professionals, discussion with sexual partners, history of pregnancy, desire time to have a child in the future, and history of rape were factors significantly associated with the use of modern contraceptives. Most of the participants' reasons for the lack of use of modern contraceptives were fear of its side effects.

Street women are a segment of the population in absolute poverty, which they suffer from the major problems of unwanted pregnancy and sexually transmitted diseases. Besides this issue, its consequences necessitate the use of modern contraceptives. This study aimed to determine the utilization and associated factors, and explore the key barriers to modern contraceptive utilization among street women in Dire Dawa.In this study, a community-based cross-sectional study design was conducted among all censuses and 615 reproductive-aged street women from February 16th to April 10, 2021. Face-to-face and in-depth interviews were employed to generate data for both methods. Data were analyzed using the SPSS software version 25 and a thematic approach for quantitative and qualitative, respectively.The findings of this study showed that the proportion of street women who currently used modern contraceptives was 279 (50.3%). Factors significantly associated were age, distance from the health facility, discussion with health professionals, discussion with sexual partners, history of pregnancy, desire time to have a child, and history of rape. The key barriers to using modern contraceptives are fear of side effects, misperceptions, and the desire to have a child.In conclusion: this study demonstrated that the proportion of street women currently using modern contraceptives was low. Health professionals and health extension workers should give health education that integrates well-organized street women's groups and community health extension workers that may help reduce women's fear of potential side effects. To correct the misperceptions and myths about modern contraceptives too.