RESUMO
INTRODUCTION: Bromocriptin has been associated with stroke and myocardial infarction in the postpartum period. We report on the case of a patient who developed digital ischemia while receiving this drug. EXEGESIS: Mrs D, 28 years old presented with digital ischemia occurring five days after the introduction of bromocriptin. Magnetic resonance imaging also displayed stroke in the area of the right posterior cerebellar artery. The course was favourable after discontinuation of the drug. DISCUSSION: Bromocriptin is an ergot derivative with dopaminergic agonist properties. A paradoxical vasoconstriction is rarely associated with vascular ischemic complications, including digital ischemia.
Assuntos
Bromocriptina/efeitos adversos , Agonistas de Dopamina/efeitos adversos , Dedos/irrigação sanguínea , Isquemia/induzido quimicamente , Adulto , Bromocriptina/administração & dosagem , Depressão Pós-Parto/tratamento farmacológico , Agonistas de Dopamina/administração & dosagem , Feminino , HumanosRESUMO
Experiments were carried out in order to obtain information on the uptake characteristics of metals in the algal and fungal components of lichens. The uptake of (115)Cd, (65)Zn, (64)Cu, (140)La, (187)W and (76)As in the alga Scenedesmus pannonicus, subsp. Berlin and the fungus Aureobasidium pullulans was determined at pH 7 and 5 respectively, in 4 h experiments varying with respect to temperature and Ca(2+) solution concentrations. Furthermore, the effects of pre-rinsing the cell suspensions on metal uptake were investigated.Pre-rinsing resulted in decreased uptake of W and As by algae and in increased uptake of all elements measured by fungi, which may be attributed to combined effects of starvation and changing densities.For algae, the uptake rates of As, W, Zn and Cd were markedly increased at the highest temperature employed. For Cu and La hardly any effects of temperature were observed, indicating the absence of metabolically controlled uptake. For fungi, but for As no relation of uptake with temperature could be determined.The presence of Ca(2+) ions in the solution applied hardly affected the uptake of As but resulted in increased uptake of W by both the algae and the fungi. The effects of Ca(2+) on the uptake of Cu and La were relatively small, probably due to specific binding sites in the cell walls for Cu and to the 'supercalcium' status of the La-ion.The presence of Ca(2+) caused decreased uptake of Cd(2+) and Zn(2+) by algae, but hardly affected the uptake of Zn(2+) by fungi.The results indicate component-specific uptake and accumulation behaviour in intact lichens.
RESUMO
Experiments were carried oud in order to obtain information on the uptake characteristics of metals in the algal and fungus components of lichens. The uptake of (115)Cd, (65)Zn, (64)Cu, (140)La, (187)W, (75)Se, and (76)As in the alga Scenedesmus pannonicus, subsp. Berlin and the fungus Aureobasidium pullulans was determined during 11 days of incubation at pH 5 and pH 7. The results indicate different acid-sensitivity of the alga and the fungus. The metal uptake in the alga was generally faster at pH 7, in the fungus uptake rates were higher at pH 5. In both the alga and the fungus for different pH-values hardly any differences in ultimate metal levels could be observed for Cd(2+), Zn(2+), La(3+), and SeO inf3 (sup2-) . In algae, the ultimate levels of the accumulated anionic forms of W and As appeared to be independent of pH; in the fungi the ultimate W and As levels were higher at pH 5. No differences could be observed in the Zn(2+) accumulation capacities of both organisms. The As accumulation capacity of the alga was estimated to be about 10 times the As uptake capacity of the fungus. The results indicate the component-specific uptake and accumulatiom behaviour in intact lichens.
