Identification of new drugs to counteract anti-spike IgG-induced hyperinflammation in severe COVID-19

Previously, we and others have shown that SARS-CoV-2 spike-specific IgG antibodies play a major role in disease severity in COVID-19 by triggering macrophage hyperactivation, disrupting endothelial barrier integrity, and inducing thrombus formation. This hyperinflammation is dependent on high levels of anti-spike IgG with aberrant Fc tail glycosylation, leading to Fc{gamma} receptor hyperactivation. For development of immune-regulatory therapeutics, drug specificity is crucial to counteract excessive inflammation while simultaneously minimizing inhibition of antiviral immunity. We here developed an in vitro activation assay to screen for small molecule drugs that specifically counteract antibody-induced pathology. We identified that anti-spike induced inflammation is specifically blocked by small molecule inhibitors against SYK and PI3K. We identified SYK inhibitor entospletinib as the most promising candidate drug, which also counteracted anti-spike-induced endothelial dysfunction and thrombus formation. Moreover, entospletinib blocked inflammation by different SARS-CoV-2 variants of concern. Combined, these data identify entospletinib as a promising treatment for severe COVID-19.

Broad SARS-CoV-2 Neutralization by Monoclonal and Bispecific Antibodies Derived from a Gamma-infected Individual

The worldwide pandemic caused by SARS-CoV-2 has remained a human medical threat due to the continued evolution of multiple variants that acquire resistance to vaccines and prior infection. Therefore, it is imperative to discover monoclonal antibodies (mAbs) that neutralize a broad range of SARS-CoV-2 variants for therapeutic and prophylactic use. A stabilized autologous SARS-CoV-2 spike glycoprotein was used to enrich antigen-specific B cells from an individual with a primary Gamma variant infection. Five mAbs selected from those B cells showed considerable neutralizing potency against multiple variants of concern, with COVA309-35 being the most potent against the autologous virus, as well as against Omicron BA.1 and BA.2. When combining the COVA309 mAbs as cocktails or bispecific antibody formats, the breadth and potency was significantly improved against all tested variants. In addition, the mechanism of cross-neutralization of the COVA309 mAbs was elucidated by structural analysis. Altogether these data indicate that a Gamma-infected individual can develop broadly neutralizing antibodies.

Mapping the antigenic diversification of SARS-CoV-2

Large-scale vaccination campaigns have prevented countless hospitalizations and deaths due to COVID-19. However, the emergence of SARS-CoV-2 variants that escape from immunity challenges the effectiveness of current vaccines. Given this continuing evolution, an important question is when and how to update SARS-CoV-2 vaccines to antigenically match circulating variants, similar to seasonal influenza viruses where antigenic drift necessitates periodic vaccine updates. Here, we studied SARS-CoV-2 antigenic drift by assessing neutralizing activity against variants-of-concern (VOCs) of a unique set of sera from patients infected with a range of VOCs. Infections with D614G or Alpha strains induced the broadest immunity, while individuals infected with other VOCs had more strain-specific responses. Omicron BA.1 and BA.2 were substantially resistant to neutralization by sera elicited by all other variants. Antigenic cartography revealed that Omicron BA.1 and BA.2 are antigenically most distinct from D614G, associated with immune escape and likely requiring vaccine updates to ensure vaccine effectiveness.

A public antibody class recognizes a novel S2 epitope exposed on open conformations of SARS-CoV-2 spike

Delineating the origins and properties of antibodies elicited by SARS-CoV-2 infection and vaccination is critical for understanding their benefits and potential shortcomings. Therefore, we investigated the SARS-CoV-2 spike (S)-reactive B cell repertoire in unexposed individuals by flow cytometry and single-cell sequencing. We found that [~]82% of SARS-CoV-2 S-reactive B cells show a naive phenotype, which represents an unusually high fraction of total human naive B cells ([~]0.1%). Approximately 10% of these naive S-reactive B cells shared an IGHV1-69/IGKV3-11 B cell receptor pairing, an enrichment of 18-fold compared to the complete naive repertoire. A proportion of memory B cells, comprising switched ([~]0.05%) and unswitched B cells ([~]0.04%), was also reactive with S and some of these cells were reactive with ADAMTS13, which is associated with thrombotic thrombocytopenia. Following SARS-CoV-2 infection, we report an average 37-fold enrichment of IGHV1-69/IGKV3-11 B cell receptor pairing in the S-reactive memory B cells compared to the unselected memory repertoire. This class of B cells targets a previously undefined non-neutralizing epitope on the S2 subunit that becomes exposed on S proteins used in approved vaccines when they transition away from the native pre-fusion state because of instability. These findings can help guide the improvement of SARS-CoV-2 vaccines.

Emerging SARS-CoV-2 variants of concern evade humoral immune responses from infection and vaccination

Emerging SARS-CoV-2 variants pose a threat to human immunity induced by natural infection and vaccination. We assessed the recognition of three variants of concern (B.1.1.7, B.1.351 and P.1) in cohorts of COVID-19 patients ranging in disease severity (n = 69) and recipients of the Pfizer/BioNTech vaccine (n = 50). Spike binding and neutralization against all three VOC was substantially reduced in the majority of samples, with the largest 4-7-fold reduction in neutralization being observed against B.1.351. While hospitalized COVID-19 patients and vaccinees maintained sufficient neutralizing titers against all three VOC, 39% of non-hospitalized patients did not neutralize B.1.351. Moreover, monoclonal neutralizing antibodies (NAbs) show sharp reductions in their binding kinetics and neutralizing potential to B.1.351 and P.1, but not to B.1.1.7. These data have implications for the degree to which pre-existing immunity can protect against subsequent infection with VOC and informs policy makers of susceptibility to globally circulating SARS-CoV-2 VOC.

[The use of artificial neural networks to classify the social vulnerability of municipalities in Rio Grande do Norte State, Brazil]. / Uso de redes neurais artificiais para classificação de municípios quanto à vulnerabilidade social no Estado do Rio Grande do Norte, Brasil.

The objective was to apply artificial neural networks to classify municipalities (counties) in Rio Grande do Norte State, Brazil, according to their social vulnerability. This was an ecological study using 17 variables that reflected epidemiological, demographic, socioeconomic, and educational indicators for the year 2010. The sources were the Human Development Atlas for Brazil and the Brazilian Institute of Geography and Statistics. For classification of the municipalities, the study applied the artificial neural networks of the PNN and Multilayer feedforward types, resulting in a classification in five categories of vulnerability: very high, high, medium, low, and very low. The networks' training phase used the minimum and maximum values, 25th and 75th percentiles, and medians for the 17 selected variables. The Multilayer feedforward network with six nodes showed the best results. The municipalities from the Metropolitan Area (Natal, Parnamirim) and the eastern and western Seridó micro-regions (Caicó, Currais Novos, São José do Seridó, Jardim do Seridó, Parelhas, Carnaúba dos Dantas) showed the lowest levels of vulnerability. The municipalities with high and very high vulnerability were located in the East of the state, in the micro-regions of the Northeast Coast (João Câmara, Touros, Caiçara do Rio dos Ventos) and Southern Coast (Nísia Floresta, São José do Mipibu, Arês, Canguaretama). The neural network classified the municipalities with high precision, distinguishing those with extreme vulnerability from those with better social indicators.

[Bibliometric analysis of the scientific evidence on violence perpetrated against the elderly]. / Análise bibliométrica das evidências científicas sobre violência contra a pessoa idosa.

The scope of this study is violence perpetrated against the elderly. It aims to analyze the international scientific production on violence against the elderly. It involved bibliometric research carried out in the ISI Web of Knowledge/Web of ScienceTM database, in which the search terms "elder,"violence" or "abuse" and "health care" were used, in the period between the years 1991 and 2016. The data were analyzed considering the evolution of the annual publications, the journals with the highest number of records, the authors with the highest number of publications, the number of articles distributed by authors' country of origin, and articles with the highest impact. A total of 267 published records in 174 different journals indexed to the database in question were identified and were written by 901 authors with links to 410 institutions located in 39 countries. In the descriptive analysis of the content of the top journals on the topic and of the most cited articles there was potential for the development of the topic, since there is a need for more data on interventions in cases of violence against the elderly, with a multidisciplinary approach, as well as conducting more research on clinical manifestations, quality of life and its economic impact on the use of health services.

O estudo tem como objeto as violências contra a pessoa idosa. Objetiva analisar a produção científica internacional sobre violência contra a pessoa idosa. Trata-se de uma pesquisa bibliométrica realizada na base de dados "ISI Web of Knowledge/Web of Sciencetm", na qual foram usados os termos de busca: "elder*, violence* ou abuse* e health care", no recorte temporal entre os anos 1991 e 2016. Os dados foram analisados considerando a trajetória de evolução anual das publicações, os periódicos com maior quantidade de registros, os autores com maior quantidade de publicações, a quantidade de artigos distribuídos por país de origem dos autores e os artigos de maior impacto. Foram identificados 267 registros de publicação em 174 periódicos distintos indexados à base de dados em questão e foram escritos por 901 autores que possuem vínculos a 410 instituições, localizadas em 39 países. Na análise descritiva do conteúdo dos "top journals" da temática e dos artigos mais citados verificou-se potenciais para o desenvolvimento do tema visto que existe a necessidade de mais dados sobre intervenções em casos de violências contra a pessoa idosa, com abordagem multidisciplinar, bem como a realização de mais pesquisas sobre as manifestações clínicas, qualidade vida e seu impacto econômico na utilização dos serviços de saúde.

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

The rapid spread of SARS-CoV-2 has a significant impact on global health, travel and economy. Therefore, preventative and therapeutic measures are urgently needed. Here, we isolated neutralizing antibodies from convalescent COVID-19 patients using a SARS-CoV-2 stabilized prefusion spike protein. Several of these antibodies were able to potently inhibit live SARS-CoV-2 infection at concentrations as low as 0.007 {micro}g/mL, making them the most potent human SARS-CoV-2 antibodies described to date. Mapping studies revealed that the SARS-CoV-2 spike protein contained multiple distinct antigenic sites, including several receptor-binding domain (RBD) epitopes as well as previously undefined non-RBD epitopes. In addition to providing guidance for vaccine design, these mAbs are promising candidates for treatment and prevention of COVID-19.

Mortalidade por queda em idosos: uma revisão integrativa / Fall mortality in the elderly: an integrative review / Muerte por caída en los ancianos: una revisión integradora

Introdução: A Organização Mundial de Saúde avalia que aproximadamente 28% a 42% das pessoas acima de 65 anos sofrem quedas anualmente, e 5 a 10% destas evoluem para óbito. Objetivo: Verificar o perfil epidemiológico de óbitos por quedas em idosos entre 2007 e 2016. Método: Busca de artigos com descritores: Idoso; Óbito; Envelhecimento; Perfil de Saúde; Acidentes por Quedas; nas bases de dados CAPES, SciELO, BVS; entre 2007 e 2016; utilizando Idiomas: Inglês, português, espanhol; Incluídos artigos cujo objetivo avaliou os óbitos por quedas em idosos excluindo os que não possuíam informações sobre quedas ou continham a informação queda como fator de risco para mortalidade sem o desfecho óbito. Resultados: Triados oito artigos, seis utilizaram estudos retrospectivos entre 1996 a 2011 tendo o Sistema de Informação de Mortalidade (SIM) como base. Foram encontrados percentuais gerais de óbitos por quedas em idosos entre 0,61% e 0,69% e 7,15% das causas externas. A Mortalidade Específica por quedas variou entre 15 a 29%. O Coeficiente de Mortalidade Específico variou de 24,06 a 35,83/100000hab. Gênero, raça, estado civil e escolaridade não apresentaram avaliações que permitissem análise mais efetiva. Todos os estudos apontaram que quanto maior a idade, maior o risco de óbito por queda. Os estudos baseados no SIM apontaram para a limitação da qualidade do dado coletado, onde o óbito por queda pode estar mascarado por outras causas. Conclusões: Encontradas informações insuficientes para traçar o perfil epidemiológico da populaçãoidosa que vem a óbito por quedas, assim como disparidades entre taxas gerais e específicas de mortalidade. Mostra-se importante a qualificação da causa básica do óbito no preenchimento das informações do SIM, uma vez que o preenchimento incorreto pode mascarar a magnitude deste agravo, suas proporções e coeficientes, prejudicando a avaliação e alocação de políticas públicas que possam reduzir esta mortalidade (AU).

Introduction:The World Health Organization estimates that approximately 28% to 42% of people over 65 suffer falls annually, and 5 to 10% of them die. Objective: To verify the epidemiological profile of deaths due to falls in the elderly between 2007 and 2016. Method: Search for articles with descriptors: Elderly; Death; Aging; Health Profile; Falls Accidents; in the CAPES, SciELO, BVS databases; between 2007 and 2016; using Languages: English, Portuguese, Spanish; Included were articles whose objective evaluated deathsfrom falls in the elderly, excluding those who did not have information about falls or contained information about falls as a risk factor for mortality without the outcome of death. Results: Screened eight articles, six used retrospective studies between 1996 to 2011 using the Mortality Information System (SIM) as a database. General percentages of deaths from falls were found in the elderly between 0.61% and 0.69% and 7.15% of external causes. Specific mortality from falls ranged from 15 to 29%. The Specific Mortality Coefficient ranged from 24.06 to 35.83 / 100000hab. Gender, race, marital status and education did not present evaluations that would allow more effective analysis. All studies pointed out that the older the age, the greater the risk of deathfrom falls. Studies based on SIM pointed to the limitation of the quality of the data collected, where death from falls may be masked by other causes. Conclusions: Insufficient information was found to trace the epidemiological profile of the elderly population that dies from falls, as well as disparities between general and specific mortality rates. It is important to qualify the basic cause of death when filling out SIM information, since incorrect filling can mask the magnitude of this condition, its proportions and coefficients, impairing the evaluation and allocation of public policies that can reduce this mortality (AU).

Introducción:la Organización Mundial de la Saludestima que aproximadamente 28% al 42% de las personas mayores de 65 años sufren caídas anuales, y del 5 al 10% de ellas mueren. Objetivo: verificar el perfil epidemiológico de las muertes por caídas en los ancianos entre 2007-2016. Método: buscar artículos con descriptores: ancianos; Muerte; Envejecimiento Perfil de salud; Accidentes de caídas; en las bases de datos CAPES, SciELO, BVS; entre 2007 y 2016; idiomas: inglés, portugués, español; Se incluyeron artículos cuyo objetivo evaluó las muertes por caídas en los ancianos, excluyendo a aquellos que no tenían información sobre caídas o que contenían información sobre caídas como factor de riesgo de mortalidad sin el resultado de la muerte. Resultados: Ocho artículosencontrados, seis utilizaron estudios retrospectivos entre 1996 y 2011 utilizando el Sistema de Información de Mortalidad (SIM). Porcentajes generales de muertes entre 0,61% y 0,69% y 7,15% de causas externas. La mortalidad específica por caídas osciló entre 15 y 29%. El coeficiente de mortalidadespecífico varió de 24.06 a 35.83 / 100000hab. El género, la raza, el estado civil y la educación no presentaron evaluaciones que permitieran un análisis más efectivo. Todos los estudios señalaron que cuanto mayor es la edad, mayor es el riesgo de muerte por caídas. Los estudios basados en SIM señalaron la limitación de la calidad de los datos, donde la muerte por caídas puede estar enmascarada por otras causas. Conclusiones: se encontró información insuficiente para rastrear el perfil epidemiológico de la población anciana que muere por caídas, edisparidades entre las tasas de mortalidad general y específica. Es importante calificar la causa básica de muerte en laSIM, ya que un llenado incorrecto puede enmascarar la magnitud de esta condición, perjudicando la evaluación y asignación de políticas públicas que puden reducir esta mortalidad (AU).

Análise bibliométrica das evidências científicas sobre violência contra a pessoa idosa / Bibliometric analysis of the scientific evidence on violence perpetrated against the elderly

Resumo O estudo tem como objeto as violências contra a pessoa idosa. Objetiva analisar a produção científica internacional sobre violência contra a pessoa idosa. Trata-se de uma pesquisa bibliométrica realizada na base de dados "ISI Web of Knowledge/Web of Sciencetm", na qual foram usados os termos de busca: "elder*, violence* ou abuse* e health care", no recorte temporal entre os anos 1991 e 2016. Os dados foram analisados considerando a trajetória de evolução anual das publicações, os periódicos com maior quantidade de registros, os autores com maior quantidade de publicações, a quantidade de artigos distribuídos por país de origem dos autores e os artigos de maior impacto. Foram identificados 267 registros de publicação em 174 periódicos distintos indexados à base de dados em questão e foram escritos por 901 autores que possuem vínculos a 410 instituições, localizadas em 39 países. Na análise descritiva do conteúdo dos "top journals" da temática e dos artigos mais citados verificou-se potenciais para o desenvolvimento do tema visto que existe a necessidade de mais dados sobre intervenções em casos de violências contra a pessoa idosa, com abordagem multidisciplinar, bem como a realização de mais pesquisas sobre as manifestações clínicas, qualidade vida e seu impacto econômico na utilização dos serviços de saúde.

Abstract The scope of this study is violence perpetrated against the elderly. It aims to analyze the international scientific production on violence against the elderly. It involved bibliometric research carried out in the ISI Web of Knowledge/Web of ScienceTM database, in which the search terms "elder,"violence" or "abuse" and "health care" were used, in the period between the years 1991 and 2016. The data were analyzed considering the evolution of the annual publications, the journals with the highest number of records, the authors with the highest number of publications, the number of articles distributed by authors' country of origin, and articles with the highest impact. A total of 267 published records in 174 different journals indexed to the database in question were identified and were written by 901 authors with links to 410 institutions located in 39 countries. In the descriptive analysis of the content of the top journals on the topic and of the most cited articles there was potential for the development of the topic, since there is a need for more data on interventions in cases of violence against the elderly, with a multidisciplinary approach, as well as conducting more research on clinical manifestations, quality of life and its economic impact on the use of health services.

Uso de redes neurais artificiais para classificação de municípios quanto à vulnerabilidade social no Estado do Rio Grande do Norte, Brasil / The use of artificial neural networks to classify the social vulnerability of municipalities in Rio Grande do Norte State, Brazil / Uso de redes neuronales artificiales para la clasificación de municipios respecto a la vulnerabilidad social en Estado del Rio Grande do Norte, Brasil

Resumo: O objetivo foi aplicar as redes neurais artificiais para classificar os municípios do Estado do Rio Grande do Norte, Brasil, de acordo com sua vulnerabilidade social. Estudo ecológico que utilizou 17 variáveis que refletissem os indicadores epidemiológicos, demográficos, socioeconômicos e educacionais para o ano de 2010. As fontes pesquisadas foram o Atlas do Desenvolvimento Humano no Brasil e o Instituto Brasileiro de Geografia e Estatística. Para a classificação dos municípios, foram aplicadas as redes neurais artificiais, dos tipos PNN e Multilayer feedforward, resultando a classificação em cinco categorias de vulnerabilidade: muito alta, alta, média, baixa e muito baixa. A fase de treinamento das redes utilizou os valores de mínimo, máximo, percentis 25 e 75 e mediana das 17 variáveis selecionadas. A rede Multilayer feedforward com seis nós apresentou os melhores resultados. Os municípios da região metropolitana (Natal, Parnamirim), das microrregiões do Seridó oriental e ocidental (Caicó, Currais Novos, São José do Seridó, Jardim do Seridó, Parelhas, Carnaúba dos Dantas) apresentaram níveis mais baixos de vulnerabilidade. Os municípios de alta e muito alta vulnerabilidade encontram-se na mesorregião do Leste potiguar: nas microrregiões do Litoral Nordeste (municípios de João Câmara, Touros, Caiçara do Rio dos Ventos) e do Litoral Sul (Nísia Floresta, São José do Mipibu, Arês, Canguaretama). A rede neural classificou os municípios com elevada precisão, destacando os que possuem extrema vulnerabilidade daqueles que detêm os melhores indicadores sociais.

Abstract: The objective was to apply artificial neural networks to classify municipalities (counties) in Rio Grande do Norte State, Brazil, according to their social vulnerability. This was an ecological study using 17 variables that reflected epidemiological, demographic, socioeconomic, and educational indicators for the year 2010. The sources were the Human Development Atlas for Brazil and the Brazilian Institute of Geography and Statistics. For classification of the municipalities, the study applied the artificial neural networks of the PNN and Multilayer feedforward types, resulting in a classification in five categories of vulnerability: very high, high, medium, low, and very low. The networks' training phase used the minimum and maximum values, 25th and 75th percentiles, and medians for the 17 selected variables. The Multilayer feedforward network with six nodes showed the best results. The municipalities from the Metropolitan Area (Natal, Parnamirim) and the eastern and western Seridó micro-regions (Caicó, Currais Novos, São José do Seridó, Jardim do Seridó, Parelhas, Carnaúba dos Dantas) showed the lowest levels of vulnerability. The municipalities with high and very high vulnerability were located in the East of the state, in the micro-regions of the Northeast Coast (João Câmara, Touros, Caiçara do Rio dos Ventos) and Southern Coast (Nísia Floresta, São José do Mipibu, Arês, Canguaretama). The neural network classified the municipalities with high precision, distinguishing those with extreme vulnerability from those with better social indicators.

Resumen: El objetivo fue aplicar las redes neuronales artificiales para clasificar los municipios del estado de Rio Grande do Norte, Brasil, de acuerdo con su vulnerabilidad social. Se realizó un estudio ecológico que utilizó 17 variables que reflejaron los indicadores epidemiológicos, demográficos, socioeconómicos y educacionales durante el año 2010. Las fuentes investigadas fueron: el Atlas de Desarrollo Humano en Brasil y el Instituto Brasileño de Geografía y Estadística. Para la clasificación de los municipios, se aplicaron las redes neuronales artificiales de los tipos PNN y Multilayer feedforward, resultando la clasificación en cinco categorías de vulnerabilidad: muy alta, alta, media, baja y muy baja. La fase de entrenamiento de las redes utilizó los valores: mínimo, máximo, percentiles 25 y 75 y mediana de las 17 variables seleccionadas. La red Multilayer feedforward con seis nudos presentó los mejores resultados. Los municipios de la región metropolitana (Natal, Parnamirim), de las microrregiones del Seridó oriental y ocidental (Caicó, Currais Novos, São José do Seridó, Jardim do Seridó, Parelhas, Carnaúba dos Dantas) presentaron niveles más bajos de vulnerabilidad. Los municipios de alta y muy alta vulnerabilidad se encuentran en la mesorregión del este potiguar: en las microrregiones del litoral nordeste (municipios de João Câmara, Touros, Caiçara do Rio dos Ventos) y del litoral sur (Nísia Floresta, São José do Mipibu, Arês, Canguaretama). La red neuronal clasificó los municipios con elevada precisión, destacando los que poseen extrema vulnerabilidad de aquellos que ostentan los mejores indicadores sociales.

Scientific production on falls and deaths among elderly persons: a bibliometric analysis / Produção científica sobre quedas e óbitos em idosos: Uma análise bibliométrica

Objective: To map international scientific production on falls and deaths among the elderly. Method: A bibliometric study of academic papers was carried out in the ISI Web of Knowledge/Web of ScienceTM. The search terms "elderly*", "fall*" and "death*" were used for studies between 1990 and 2016. Articles from events or those still in the editing process and studies in the form of "conference proceedings", "editorial material" and "letters" were excluded, with only finished studies and complete "articles" and "reviews" considered. Results: After applying the refinement filters, 668 articles were identified during the 26 year evaluation period, published in 364 different journals indexed to the database in question. These were written by 2,958 authors with links to 1131 research institutions located in 63 countries. The articles included 22,093 references, with an average of approximately 33 references per study. Conclusion: The articles on falls and deaths among the elderly emphasize the need for more specific studies on the subject and its potential for exploration in future research. This study revealed the need for this issue to be discussed in the training of health professionals, as it represents an opportunity to deconstruct and reconstruct concepts and values that are established throughout the life of individuals, such as care related to the avoidability of falls, to improve the quality of life of this population.

Objetivo: Mapear a produção científica internacional sobre quedas e óbitos na pessoa idosa. Método: Foi realizado um estudo bibliométrico com trabalhos acadêmicos na base de dados ISI Web of Knowledge/Web of ScienceTM. Foram usados os termos de busca constantes nos Descritores em Ciências da Saúde (DeCS): "elder*", "fall*" e "death*" no recorte temporal entre 1990 e 2016, excluindo-se dos resultados os artigos provenientes de eventos ou considerados ainda em edição e registros oriundos de "proceedings papers", "editorial material" e "letter", resultando apenas trabalhos finais e completos "article" e "review" (artigos e revisões). Resultados: Após aplicados os filtros de refinamento, foram identificados 668 artigos nos 26 anos de avaliação, publicados em 364 periódicos distintos indexados à base de dados em questão, escritos por 2.958 autores que possuem vínculos com 1.131 instituições de pesquisa, localizadas em 63 países. Para a consecução desses artigos foram utilizadas 22.093 referências, com uma média de aproximadamente 33 referências por artigo. Conclusão: Os artigos sobre quedas e óbitos em idosos destacam a necessidade de estudos mais específicos sobre o tema e o seu potencial de exploração em futuros estudos. Esse estudo apontou a necessidade de discussão dessa temática na revisão de conceitos estabelecidos ao longo da vida e dos cuidados inerentes à evitabilidade da queda para melhorar a qualidade de vida dessa população.

Mortalidade por acidentes de trânsito em capital do nordeste brasileiro, 2010-2014 / Mortality for traffic accidents in a northeast brazilian capital, 2010- 2014

Introdução: Acidentes de trânsito representam grave problema de saúde e são considerados evitáveis em sua totalidade. O Brasil ocupa o terceiro lugar internacional em número de mortes no trânsito. Objetivo: Apresentar o perfil desta mortalidade na capital do Rio Grande do Norte. Metodologia: Pesquisa observacional com dados do Sistema de Informações sobre Mortalidade, ocorridos no município de Natal/RN entre 2010-2014. Resultados: Maior parte dos óbitos são do sexo masculino (82%) solteiros (53%), de cor preta (73%) abaixo de 39 anos (44%), em finais de semana (47%) período noturno (31%) e ocupantes de motos (30%). Escolaridade, ocupação e especificação do veículo indicam preenchimento deficiente da Declaração de Óbito. Taxa de mortalidade decresceu no período de 4,85 para 2,90 óbitos/100.000habitantes, queda de 40%, porém a taxa entre motociclistas aumentou 31%. Conclusões: Necessidade de políticas voltadas para um público-alvo específico e necessidade de capacitação para o preenchimento correto dos dados (AU).

Introduction: Traffic accidents represent a serious health problem and are considered avoidable in their totality. Brazil ranks third in international traffic fatalities. Objective: To present the profile of this mortality in the capital of Rio Grande do Norte. Methodology: Observational research with data from the Brazilian Mortality Information System, occurring at the city of Natal/RN between 2010-2014. Results: Most of the deaths was from male (82%), single (53%), black (73%) below 39 years (44%), at weekends (47%) night time (31%) and occupants of motorcycles (30%). Schooling, occupancy and vehicle specification, indicate insufficient completion of the Death Certificate. Mortality rate decreased in the period from 4.85 to 2.90 deaths/100,000 inhabitants, down 40%, but the rate among motorcyclists increased by 31%. Conclusions: The need for policies aimed at a specific target audience and the need for training to fill the Death Certificate data correctly (AU).