RESUMO
A female employee was exposed to lead dust for 8 h daily from 4. 5. 1982 to 20. 5. 1982. During this time conception occurred (1st day of last menses 4. 5. 82). Acute symptoms of lead intoxication were not observed in this subject but were in other employees. Measurements of lead content were started after the end of exposure and continued for 6 months until normal values were obtained. Because of the half-life of nearly 20 days for lead elimination from blood the estimated body burden at the end of exposure was about 1200 ppb. The fetal tissue samples contained between 0.4 (brain) and 7.9 (liver) micrograms lead/g dry weight. The fetal lead was mainly stored in bone, blood and liver. From the results given a delayed elimination of fetal lead is suggested.
Assuntos
Feto/análise , Intoxicação por Chumbo/metabolismo , Chumbo/análise , Doenças Profissionais/induzido quimicamente , Complicações na Gravidez/metabolismo , Feminino , Humanos , Recém-Nascido , Chumbo/sangue , Intoxicação por Chumbo/sangue , Fígado/análise , Doenças Profissionais/sangue , Gravidez , Distribuição TecidualRESUMO
To estimate the cellular immune response of workers highly exposed to mixtures of organic solvents, subpopulations of peripheral blood lymphocytes (PBLs) were analyzed. For this, the PBLs of nine floorers (aged 25-58 years, exposure time 8-35 years) were subsequently labelled with monoclonal antibodies OKT4, OKT8, OKT11, anti-Leu 7 and anti-Leu 12. Analysis was made by a FACS IV cell sorter (Becton-Dickinson, USA). The control group consisted of matched pairs of healthy donors. In the exposed group we found a decrease in the OKT11 (all) T cell fraction, a decrease in the OKT4 helper cells, an increase in the anti-Leu 7 positive cells, mostly natural killer cells, an important increase in anti-Leu 12 labelled T cells, i.e., human B-lymphocytes, and no differences in the OKT8 suppressor cells. Total fluorescence intensity profiles between the exposed and the unexposed group did not differ, i.e., the marker density on the cell surfaces remained unchanged. Similar changes in lymphocyte subpopulations are found in states of immunodeficiency and immunogenetic forms of aplastic anemia, a disease whose etiological relationship may be due to long-term exposure to organic solvents.
