RESUMO
The dried rhizomes of Indonesian ginger, Zingiber officinale, were investigated for antirhinoviral activity in the plaque reduction test. Fractionation by solvent extraction, solvent partition, and repeated chromatography guided by bioassay, allowed the isolation of several sesquiterpenes with antirhinoviral activity. The most active of these was beta-sesquiphellandrene [2] with an IC50 of 0.44 microM vs. rhinovirus IB in vitro.
Assuntos
Antivirais/isolamento & purificação , Plantas Medicinais/química , Rhinovirus/efeitos dos fármacos , Sesquiterpenos/isolamento & purificação , Antivirais/farmacologia , Células HeLa , Humanos , Espectroscopia de Ressonância Magnética , Sesquiterpenos/farmacologia , Ensaio de Placa ViralRESUMO
Two carbon-bridged analogues 11 and 15 of the potent microtubule inhibitor BW1069C85 (1) have been synthesised and evaluated for antitubulin and antitumour activity in vitro. Though the compounds were somewhat less potent than BW1069C85, significant activity against tubulin polymerisation and cell proliferation was demonstrated in the assays.
