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1.
Disabil Health J ; 16(4): 101502, 2023 10.
Artigo em Inglês | MEDLINE | ID: mdl-37482499

RESUMO

BACKGROUND: Compared to those without vision impairments, adults with low vision have higher rates of obesity and face more barriers to participation in traditional weight loss programs. OBJECTIVE: This pilot study examined the usability and helpfulness of an adaptive, evidence-based weight loss program for adults who are legally blind. METHODS: The study was a remotely delivered, single-arm weight loss trial for adults who were legally blind with a body mass index (BMI) ≥ 25. At weeks 4 and 8, participants reported usability and helpfulness of program components using a five-point scale (0-4) with higher numbers indicating greater usability and helpfulness. Weight data were collected at baseline, week 4, and week 8 using a scale with cellular technology. The adaptive 8-week weight loss program included evidence-based lifestyle recommendations for diet, physical activity, and self-weighing. The program provided support through text messages, emails, and video-based problem-solving sessions. RESULTS: Participants (N = 28) were aged 53.4 ± 10.2 years, 89.3% female, 35.7% Black, and 57.1% non-Hispanic White with an average BMI of 35.4 ± 8.8 kg/m2. Most program components had a median score of 4 for usability and helpfulness except educational materials (helpfulness, median 3). Compared to baseline weight, participants had a weight loss of 2.2 ± 2.1% (p < .001) at week 4 and 3.6 ± 3.0% (p < .001) at week 8. CONCLUSIONS: This study has provided evidence that an all-remote weight loss program can be a useable, helpful, and effective approach for adults who are legally blind. More work is needed to develop scalable, sustainable, and fully accessible evidence-based weight loss programs. TRIAL REGISTRATION: Clinicaltrials. gov identifier: NCT05419063.


Assuntos
Pessoas com Deficiência , Programas de Redução de Peso , Adulto , Feminino , Humanos , Masculino , Obesidade/terapia , Projetos Piloto , Redução de Peso , Pessoa de Meia-Idade
2.
Gene Ther ; 19(3): 295-302, 2012 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-21753794

RESUMO

Gene-directed enzyme prodrug therapy (GDEPT) is a promising and emerging strategy that attempts to limit the systemic toxicity inherent to cancer chemotherapy by means of tumor-targeted delivery and expression of an exogenous gene whose product converts nontoxic prodrug(s) into activated cytotoxic agent(s). The bacterial nitroreductase (NTR) enzyme, coupled with its substrate prodrug 5-(azaridin-1-yl)-2,4-dinitrobenzamide (CB1954), is a promising GDEPT strategy that has reached clinical trials. However, no strategy exists to visually monitor and quantitatively evaluate the therapeutic efficacy of NTR/CB1954 prodrug therapy in cells and imaging in living animals. As the success of any GDEPT is dependent upon the efficiency of transgene expression in vivo, we developed a safe, sensitive and reproducible noninvasive imaging method to monitor NTR transgene expression that would allow quantitative assessment of both therapeutic efficacy and diagnostic outcome of NTR/CB1954 prodrug therapy in the future. Here, we investigate the use of a novel fluorescent imaging dye CytoCy5S (a Cy5-labeled quenched substrate of NTR enzyme) on various cancer cell lines in vitro and in NTR-transfected tumor-bearing animals in vivo. CytoCy5S-labeled cells become fluorescent at 'red-shifted' wavelengths (638 nm) when reduced by cellular NTR enzyme and remains trapped within the cells for extended periods of time. The conversion and entrapment was dynamically recorded using a time-lapsed microscopy. Systemic and intratumoral delivery of CytoCy5S to NTR-expressing tumors in animals indicated steady and reproducible signals even 16 h after delivery (P<0.001). This is the first study to address visual monitoring and quantitative evaluation of NTR activity in small animals using CytoCy5S, and establishes the capability of NTR to function as an imageable reporter gene.


Assuntos
Aziridinas/metabolismo , Imagem Molecular , Nitrorredutases/genética , Nitrorredutases/metabolismo , Pró-Fármacos/metabolismo , Animais , Aziridinas/uso terapêutico , Linhagem Celular , Ativação Enzimática/genética , Expressão Gênica , Ordem dos Genes , Vetores Genéticos , Humanos , Mucosa Intestinal/metabolismo , Intestinos/microbiologia , Cinética , Metagenoma/genética , Camundongos , Camundongos Nus , Neoplasias/tratamento farmacológico , Neoplasias/enzimologia , Neoplasias/genética , Pró-Fármacos/uso terapêutico , Transfecção , Transplante Heterólogo
3.
J Pediatr Orthop ; 9(1): 44-8, 1989.
Artigo em Inglês | MEDLINE | ID: mdl-2915038

RESUMO

The clinical and radiographic results of posteromedial release performed on 30 patients (44 feet) were assessed. The patients were divided into three groups based on their average age at the time of operation (early, 4.4 months; middle, 9.1 months; and late, 16.1 months). All patients had similar preoperative deformity, surgical management, and postoperative treatment. The outcomes of all three groups were similar with the exception of hindfoot-to-forefoot alignment and hindfoot varus correction. The early group demonstrated better clinical and radiologic foot alignment and had the lowest incidence of radiologic tarsal deformities (7 vs. 28% in the middle group and 35% in the late group).


Assuntos
Pé Torto Equinovaro/cirurgia , Tendões/cirurgia , Tornozelo/fisiologia , Pré-Escolar , Pé Torto Equinovaro/diagnóstico por imagem , Feminino , Seguimentos , Humanos , Lactente , Masculino , Métodos , Movimento , Exame Físico , Radiografia
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