RESUMO
PURPOSE: We evaluated the effect of three-dimensional conformal radiation therapy (3D-CRT) with or without hormonal therapy (HT) on sexual function (SF) in prostate cancer patients whose SF was known before all treatment. METHODS AND MATERIALS: Between March 1996 and March 1999, 144 patients received 3D-CRT (median dose = 70.2 Gy, range 66.6-79.2 Gy) for prostate cancer and had pre- and post-therapy SF data. All SF data were obtained with the O'Leary Brief SF Inventory, a self-administered, multidimensional, validated instrument. We defined total sexual potency as erections firm enough for penetration during intercourse. Mean follow-up time was 21 months (SD +/- 11 months). The Wilcoxon signed-rank test was used to test for significance of the change from baseline. RESULTS: Before 3D-CRT, 87 (60%) of 144 men were totally potent as compared to only 47 (47%) of 101 at 1-year follow-up. Of the 60 men totally potent at baseline and followed for at least 1 year, 35 (58%) remained totally potent. These changes corresponded to a significant reduction in SF (p < 0.05). Patients who had 3D-CRT alone were more likely to be totally potent at 1 year than those receiving 3D-CRT with HT (56% vs. 31%, p = 0.012); however, they were also more likely to be potent at baseline (71% vs. 44%, p = 0.001). Although these two groups had a significant reduction in SF from baseline, their change was not significantly different from each other. CONCLUSION: These data indicate that 3D-CRT causes a significant reduction in total sexual potency as compared to pretreatment baseline. The addition of HT does not appear to increase the risk of sexual dysfunction.
Assuntos
Antagonistas de Androgênios/efeitos adversos , Antineoplásicos Hormonais/efeitos adversos , Disfunção Erétil/etiologia , Ereção Peniana/efeitos dos fármacos , Ereção Peniana/efeitos da radiação , Neoplasias da Próstata/fisiopatologia , Radioterapia Conformacional/efeitos adversos , Idoso , Antagonistas de Androgênios/uso terapêutico , Antineoplásicos Hormonais/uso terapêutico , Quimioterapia Adjuvante , Disfunção Erétil/induzido quimicamente , Hormônio Liberador de Gonadotropina/agonistas , Humanos , Masculino , Terapia Neoadjuvante , Neoplasias da Próstata/tratamento farmacológico , Neoplasias da Próstata/radioterapia , Inquéritos e QuestionáriosAssuntos
Aprendizagem por Discriminação , Percepção de Forma , Imaginação , Memória , Percepção Visual , Atenção , Criança , Humanos , Teoria da InformaçãoRESUMO
Recent evidence suggests that while pictures are more easily recognized, discriminated, associated, and recalled than their corresponding verbal labels, this is not the case in concept acquisition/utilization tasks. If such evidence is interpreted in terms of a "frequency theory" perspective, one would expect the typically obtained frequency judgment differences between pictures and words to be reduced if "conceptual" frequency judgments are required. This expectation was confirmed in three experiments.
