RESUMO
The US3 protein kinase is conserved over the alphaherpesvirus subfamily. Increasing evidence shows that, although the kinase is generally not required for virus replication in cell culture, it plays a pivotal and in some cases an essential role in virus virulence in vivo. The US3 protein is a multifunctional serine/threonine kinase that is involved in viral gene expression, virion morphogenesis, remodelling the actin cytoskeleton and the evasion of several antiviral host responses. In the current review, both the well conserved and virus-specific functions of alphaherpesvirus US3 protein kinase orthologues will be discussed.
Assuntos
Alphaherpesvirinae/enzimologia , Alphaherpesvirinae/fisiologia , Proteínas Serina-Treonina Quinases/genética , Proteínas Serina-Treonina Quinases/metabolismo , Proteínas Virais/genética , Proteínas Virais/metabolismo , Alphaherpesvirinae/genética , Alphaherpesvirinae/patogenicidade , Animais , Sequência Conservada , Citoesqueleto/metabolismo , Humanos , Virulência , Fatores de Virulência/genética , Fatores de Virulência/metabolismo , Montagem de Vírus , Replicação ViralRESUMO
The concentration of the three components of the retinol circulating complex demonstrates in healthy male infants, but not in females, a transient elevation culminating at 5-6 months after birth. This trimolecular peak is significantly less elevated in bilateral cryptorchid babies. The rise of the retinol related parameters seems directly induced by the testosterone hypersecretion previously described in male infants at 2-3 months. The delay in the liver response in terms of retinol secretion appears to depend on a temporary functional immaturity and/or a transitory depression of the hepatic protein-synthesizing machinery. The surge of the retinol circulating complex could play a crucial role in the O-mannosylation of several glycoproteins involved in male sexual differentiation.
