Brain metastasis from an unknown primary, or primary brain tumour? A diagnostic dilemma.

Brain metastasis is increasingly common, affecting 20%-40% of cancer patients. After diagnosis, survival is usually limited to months in these patients. Treatment for brain metastasis includes whole-brain radiation therapy, surgical resection, or both. These treatments aim to slow progression of disease and to improve or maintain neurologic function and quality of life.Although less common, primary brain tumours produce symptoms that are similar to those of brain metastasis. Glioblastoma, the most common malignant tumour of the brain, has a median survival of less than 12 months. Patients are often treated with surgical resection followed by radical radiation therapy and chemotherapy.Here, we present 2 separate cases of lesions in the brain radiologically compatible with brain metastasis. In both cases, no primary cancer site had been established, and neurosurgical intervention was sought to obtain a pathologic diagnosis. Both cases were pathologically confirmed as glioblastoma. These cases demonstrate the importance of differentiation between brain metastases and primary brain tumours to ensure that the appropriate management strategy is implemented.

Dissolved oxygen--a target indicator in determining use of the Gulf of Kachchh waters.

Spatial and temporal variations of Dissolved Oxygen (DO) and Biochemical Oxygen Demand (BOD) in the Gulf of Kachchh (GoK), India are assessed based on data collected since 1976. DO concentrations in the interior GoK vary within a narrow range (6.05-6.86 mg l(-1)), whereas near-shore waters show wider variations (3.5-7.8 mg l(-1)). The DO concentration levels in the Gulf waters are close to saturation, varying from 75.4% to 108.6%, which is much higher than the 60% saturation level set for the SW-1 waters. BOD-DO simulation shows that when effluents containing a BOD concentration of 50.0 mg l(-1) are introduced at three select locations, DO reduces from 5.1 mg l(-1) to 3.1, 5.0 and 3.8 mg l(-1), respectively, indicating a strong sensitivity to effluent load. Based on the DO analysis, BOD assimilation capacity of coastal waters around the Marine National Park (MNP) and Marine Sanctuary (MS) in the Gulf is determined. DO available for utilization for various categories of water use is illustrated, keeping in mind the ecology of MNP and MS areas. The significance of DO as a target indicator to zone the Gulf for different water use, is highlighted in this study.

Tidal eddies in a semi-enclosed basin: a model study.

A modeling study has been carried out to support a Marine Management Plan for the Gulf of Kachchh, India and here the hydrodynamic part of the programme is described. The hydrodynamic model accurately predicts the tides and tidal currents present in the Gulf and these have been validated with the measured data, albeit at only a few locations. The time averaged residual currents obtained from the model for one lunar cycle clearly reproduce the complex, small-scale, topographically induced flows with several eddies. The existence of a dynamic barrier along Sikka-Mundra section, which divides the Gulf into two distinct dynamic systems, is very evident. The model is further used to predict the movement of surface floating particles launched at different locations in the Gulf, as an aid to determining floating pollutants. The results indicate that industries discharging wastes upstream of the barrier should use extreme caution, as these will remain in the vicinity for at least one lunar cycle.