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1.
Phys Rev E Stat Nonlin Soft Matter Phys ; 84(6 Pt 1): 061114, 2011 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-22304047

RESUMO

We consider a particle immersed in a thermal reservoir and simultaneously subjected to an external random force that drives the system to a nonequilibrium situation. Starting from a Langevin equation description, we derive exact expressions for the mean-square displacement and the velocity autocorrelation function of the diffusing particle. An effective temperature is introduced to characterize the deviation from the internal equilibrium situation. Using a power-law force autocorrelation function, the mean-square displacement and the velocity autocorrelation function are analytically obtained in terms of Mittag-Leffler functions. In this case, we show that the present model exhibits a superdiffusive regime as a consequence of the competition between passive and active processes.


Assuntos
Difusão , Processos Estocásticos , Temperatura
2.
Phys Rev E Stat Nonlin Soft Matter Phys ; 80(2 Pt 1): 021111, 2009 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-19792081

RESUMO

A theoretical framework for analyzing stochastic data from single-particle tracking in viscoelastic materials and under the influence of a trapping potential is presented. Starting from a generalized Langevin equation, we found analytical expressions for the two-time dynamics of a particle subjected to a harmonic potential. The mean-square displacement and the velocity autocorrelation function of the diffusing particle are given in terms of the time lag. In particular, we investigate the subdiffusive case. Using a power-law memory kernel, exact expressions for the mean-square displacement and the velocity autocorrelation function are obtained in terms of Mittag-Leffler functions and their derivatives. The behaviors for short-, intermediate-, and long-time lags are investigated in terms of the involved parameters. Finally, the validity of usual approximations is examined.

3.
Phys Rev E Stat Nonlin Soft Matter Phys ; 80(1 Pt 1): 011101, 2009 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-19658647

RESUMO

The diffusive behavior of a harmonic oscillator driven by a Mittag-Leffler noise is studied. Using the Laplace analysis we derive exact expressions for the relaxation functions of the particle in terms of generalized Mittag-Leffler functions and its derivatives from a generalized Langevin equation. Our results show that the oscillator displays an anomalous diffusive behavior. In the strictly asymptotic limit, the dynamics of the harmonic oscillator corresponds to an oscillator driven by a noise with a pure power-law autocorrelation function. However, at short and intermediate times the dynamics has qualitative difference due to the presence of the characteristic time of the noise.

4.
Phys Rev E Stat Nonlin Soft Matter Phys ; 80(1 Pt 1): 011912, 2009 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-19658734

RESUMO

Intracellular transport of large cargoes, such as organelles, vesicles, or large proteins, is a complex dynamical process that involves the interplay of adenosine triphosphate-consuming molecular motors, cytoskeleton filaments, and the viscoelastic cytoplasm. In this work we investigate the motion of pigment organelles (melanosomes) driven by myosin-V motors in Xenopus laevis melanocytes using a high-spatio-temporal resolution tracking technique. By analyzing the obtained trajectories, we show that the melanosomes mean-square displacement undergoes a transition from a subdiffusive to a superdiffusive behavior. A stochastic theoretical model, which explicitly considers the collective action of the molecular motors, is introduced to generalize the interpretation of our data. Starting from a generalized Langevin equation, we derive an analytical expression for the mean square displacement, which also takes into account the experimental noise. By fitting theoretical expressions to experimental data we were able to discriminate the exponents that characterize the passive and active contributions to the dynamics and to estimate the "global" motor forces correctly. Then, our model gives a quantitative description of active transport in living cells with a reduced number of parameters.


Assuntos
Actinas/metabolismo , Difusão , Espaço Intracelular/metabolismo , Modelos Biológicos , Miosina Tipo V/metabolismo , Animais , Transporte Biológico , Elasticidade , Melanossomas/metabolismo , Reologia , Processos Estocásticos , Viscosidade , Xenopus laevis/metabolismo
5.
Phys Rev E Stat Nonlin Soft Matter Phys ; 77(3 Pt 1): 031123, 2008 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-18517345

RESUMO

We investigate the memory effects present in the asymptotic dynamics of a classical harmonic oscillator governed by a generalized Langevin equation. Using Laplace analysis together with Tauberian theorems we derive asymptotic expressions for the mean values, variances, and velocity autocorrelation function in terms of the long-time behavior of the memory kernel and the correlation function of the random force. The internal and external noise cases are analyzed. A simple criterion to determine if the diffusion process is normal or anomalous is established.

6.
Phys Rev E Stat Nonlin Soft Matter Phys ; 75(4 Pt 1): 042102, 2007 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-17500938

RESUMO

We introduce a Mittag-Leffler correlated random force leading to anomalous diffusion. Starting from a generalized Langevin equation, and using Laplace analysis we derive exact expressions for the mean values, variances and diffusion coefficient for a free particle in terms of generalized Mittag-Leffler functions and its derivatives. The asymptotic behavior of these quantities are obtained, from which the anomalous diffusion behavior of the particle is displayed.

7.
Phys Rev E Stat Nonlin Soft Matter Phys ; 73(1 Pt 2): 016111, 2006 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-16486220

RESUMO

We study the effect of a disordered or fractal environment in the irreversible dynamics of a harmonic oscillator. Starting from a generalized Langevin equation and using Laplace analysis, we derive exact expressions for the mean values, variances, and velocity autocorrelation function of the particle in terms of generalized Mittag-Leffler functions. The long-time behaviors of these quantities are obtained and the presence of a whip-back effect is analyzed.

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