RESUMO
Background Hip fractures cause substantial morbidity and mortality worldwide, and the coronavirus disease 2019 (COVID-19) pandemic has only worsened the global burden. Increased 120-day mortality is well established in the literature among hip fractures with COVID-19. However, the risk factors associated with mortality have been poorly understood. We aimed to determine the risk factors associated with increased 120-day mortality among hip fractures with COVID-19. Methods Seventy patients with hip fractures with confirmed COVID-19 infection between March 2020 and December 2021 were included. Thirty-three patients who died within 120 days of admission were allotted to the non-survivor group and the rest 37 patients were allotted to the survivor group. Various parameters such as demographic variables, Nottingham Hip Fracture Score (NHFS), Charlson Comorbidity Index (CCI), American Society of Anesthesiologists (ASA), Abbreviated Mental Score Test (AMTS), National Early Warning Score (NEWS), fracture type, operation type, and delay in surgery were compared between the groups to determine the risk factors for increased mortality. Multivariate regression analysis was performed to know the independent association with increased mortality. Results A total of 33 patients died within 120 days giving the 120-day mortality rate of 47.1%. Baseline parameters such as ASA, AMTS on admission, NEWS on admission, and type of residence did not significantly affect mortality. The mean NHFS was significantly high in non-survivors (5.38 ± 1.52) compared to survivors (4.40 ± 1.75) (p < 0.001). Similarly, mean CCI was also significantly high in non-survivors (5.58 ± 1.74) compared to survivors (4.76 ± 2.29) (p < 0.001). A total of 70% (seven out of 10) of patients with delayed surgery of more than 36 hours from the admission died within 120 days of admission (p < 0.001). Mortality was significantly higher in patients who underwent internal fixation of fractures like a dynamic hip screw (DHS) or intramedullary (IM) nailing than in those who underwent hemiarthroplasty or total hip arthroplasty (THA). Post-operative parameters such as early mobilization and the multidisciplinary approach to review these patients made no difference to the mortality. Multivariate regression analysis of the parameters that made a significant difference in the mortality showed that delay in surgery and type of surgery (internal fixation) independently increased the mortality among these patients (p < 0.001). However, NHFS and CCI were not independently affecting the mortality among hip fractures with concomitant COVID-19. Conclusion The 120-day mortality rate among patients with hip fractures with concomitant COVID-19 was 47.1%. Delay in surgery of more than 36 hours and patients who underwent internal fixation were independent risk factors associated with increased mortality among these patients.
RESUMO
Hip fractures commonly occur in elderly patients with multiple comorbidities. Contracting coronavirus disease 2019 (COVID-19) when healing from hip fractures places the patients at a higher risk of respiratory compromise and death. This study aimed to compare the 30- and 90-day mortality rates of patients with hip fracture with and without COVID-19. The secondary aim was to determine the impact of COVID-19 on the parameters of morbidity such as health complications and length of hospital stay. All patients with hip fractures who presented to our hospital between March and December 2020 were classified into one of two subgroups: those with a clinical and/or laboratory diagnosis of COVID-19 and those without. Patient demographics, American Society of Anesthesiologists score, Nottingham Hip Fracture Score, Charlson Comorbidity Index, complications, length of stay, and 30- and 90-day mortality rates were measured in patients with hip fractures with and without a clinical diagnosis of COVID-19. We found that COVID-19 infection independently increased the 30- and 90-day mortality rates, respiratory complications, and length of hospital stay in patients with hip fractures. This is the first study to report the 90-day mortality of COVID-19 infection in such patients.
