[Toxicity dynamics of anionic dyes in the air of a work place and long-term effects after absorption through the skin]. / Toksikodinamika anionnykh aérokrasitelei i otdalennye posledstviia pri postuplenii cherez kozhnye pokrovy.

The study covered 10 types of anion dyes for leather: Crimson 4RT, Gray M, Solid Blue, Red 8S, Black N, Brown 46, 673, 911, 551, 557. According to LD50 criterion they all were assigned to IV jeopardy class. It instilled per os 30 times, the chemicals induced mild hemotoxic effect similar to that of methemoglobin-formers, in half of the cases affected gonads. Allergic and local irritating skin effects were unusual. Solid Blue and Crimson 4RT dyes were subjected to inhalation trials. Limcf for those two equal 51.8 and 38.0 mg/m3 respectively Limch--8.3 and 7.1 mg/m3, measured through changes in red blood parameters, behavioral response and other reactions. With consideration of Limch, toxicity for gonads and embryos, mutagenicity, the authors justified the MAC for Crimson 4RT dye in the air of workplace--1 mg/m3 (II jeopardy class), for Solid Blue dye--5 mg/m3 (III jeopardy class).

[The detection of the genotoxic and mutagenic activities of disperse azo dyes for their hygienic standardization]. / Vyiavlenie genotoksicheskoi i mutagennoi aktivnosti dispersnykh azokrasitelei s tsel'iu ikh gigienicheskogo normirovaniia.

Evaluating level and synthesis of DNA in liver cells, counting occurrence of dominant lethal mutations, the authors studied molecular and genetic effects of dispersed polyaether mononitrodyes Orange 2K and Red-Brown G after the peroral administration and the chronic inhalation (2.5 and 4 months). Red-Brown G examined in acute and chronic exposures appeared to be powerful mutagen. Orange 2K induced minor changes of nuclear DNA functioning in liver cells, if compared to Red-Brown G. In Dominant Lethal Mutations Test both dyes were assigned to mild mutagens. The diagnosed effects are used for setting hygienic standards in the air of workplace.