Hybrid active and passive local shimming (HAPLS) for two-region MRI.

PURPOSE: An MRI scanner is equipped with global shim systems for shimming one region of interest (ROI) only. However, it often fails to reach state-of-the-art when shimming two isolated regions of interest simultaneously, even though the two-area shimming can be essential in scan scenarios, such as bilateral breasts or dyadic brains. To address these challenges, a hybrid active and passive local shimming technique is proposed to simultaneously shim two isolated region-of-interest areas within the whole FOV. METHODS: A local passive shimming system is constructed by optimized bilateral ferromagnetic chip arrays to compensate for the magnet's significant high-order B0 inhomogeneities at the boundary of the manufacturer's specified homogeneous volume, thus locally improving the available FOV. The local active shimming consists of 40-channel DC loops powered by 64-channel current amplifiers. With the optimized current distribution, active shimming can correct the residual low-order B0 inhomogeneities and subject-specific field inhomogeneities. In addition, active shimming is used to homogenize the center frequencies of the two regions. RESULTS: With the implementation of the hybrid active and passive local shimming, the 95% peak-to-peak was reduced from 1.92 to 1.12 ppm by 41.7%, and RMS decreased from 0.473 to 0.255 ppm by 46.1% in a two-phantom experiment. The volume ratio containing MR voxels within a 0.5-ppm frequency span increased from 64.3% to 81.3% by 26.3%. CONCLUSION: The proposed hybrid active and passive local shimming technique uses both passive and active local shimming, and it can efficiently shim two areas simultaneously, which is an unmet need for a commercial MRI scanner.

Feasibility of diffusion weighting with a local inside-out nonlinear gradient coil for prostate MRI.

PURPOSE: Prostate cancer remains the second leading cancer killer of men, yet it is also a disease with a high rate of overtreatment. Diffusion-weighted imaging (DWI) has shown promise as a reliable, grade-sensitive imaging method, but it is limited by low image quality. Currently, DWI quality image is directly related to low gradient amplitudes, since weak gradients must be compensated with long echo times. METHODS: We propose a new type of MRI accessory, an "inside-out" and nonlinear gradient, whose sole purpose is to deliver diffusion encoding to a region of interest. Performance was simulated in OPERA and the resulting fields were used to simulate DWI with two-compartment and kurtosis models. Experiments with a nonlinear head gradient prove the accuracy of DWI and apparent diffusion coefficient (ADC) maps encoded with nonlinear gradients. RESULTS: Simulations validated thermal and mechanical safety while showing a 5- to 10-fold increase in gradient strength over prostate. With these strengths, lesion contrast to noise ratio in ADC maps approximately doubled for a range of anatomical positions. Proof-of-principle experiments show that spatially varying b-values can be corrected for accurate DWI and ADC. CONCLUSIONS: Dedicated nonlinear diffusion encoding hardware could improve prostate DWI.

A phantom based laser marking workflow to visually assess geometric image distortion in magnetic resonance guided radiotherapy.

Magnetic resonance (MR)-only workflows require quality assurance due to potential dosimetric impacts of using geometry distorted MR images in radiotherapy planning. MR-visible silicone-based fiducials were arranged in regular 3D structures to cover extended imaging volumes. The scanner's patient marking workflow with a 2-axes movable laser bridge allowed to visually check geometric distortions of each MR reconstructed fiducial against its true position in 3D space. A measurement resolution and uncertainty of the order of 0.5 mm in sagittal and coronal, and 1 mm in transversal direction was found. The proposed workflow required 1 min of evaluation time per fiducial position, and a 9 min 3D MR volume acquisition.

The temperature dependence of gradient system response characteristics.

PURPOSE: The gradient system transfer function (GSTF) characterizes the frequency transfer behavior of a dynamic gradient system and can be used to correct non-Cartesian k-space trajectories. This study analyzes the impact of the gradient coil temperature of a 3T scanner on the GSTF. METHODS: GSTF self- and B0 -cross-terms were acquired for a 3T Siemens scanner (Siemens Healthcare, Erlangen, Germany) using a phantom-based measurement technique. The GSTF terms were measured for various temperature states up to 45°C. The gradient coil temperatures were measured continuously utilizing 12 temperature sensors which are integrated by the vendor. Different modeling approaches were applied and compared. RESULTS: The self-terms depend linearly on temperature, whereas the B0 -cross-term does not. Effects induced by thermal variation are negligible for the phase response. The self-terms are best represented by a linear model including the three gradient coil sensors that showed the maximum temperature dependence for the three axes. The use of time derivatives of the temperature did not lead to an improvement of the model. The B0 -cross-terms can be modeled by a convolution model which considers coil-specific heat transportation. CONCLUSION: The temperature dependency of the GSTF was analyzed for a 3T Siemens scanner. The self- and B0 -cross-terms can be modeled using a linear and convolution modeling approach based on the three main temperature sensor elements.

Gradient waveform pre-emphasis based on the gradient system transfer function.

PURPOSE: The gradient system transfer function (GSTF) has been used to describe the distorted k-space trajectory for image reconstruction. The purpose of this work was to use the GSTF to determine the pre-emphasis for an undistorted gradient output and intended k-space trajectory. METHODS: The GSTF of the MR system was determined using only standard MR hardware without special equipment such as field probes or a field camera. The GSTF was used for trajectory prediction in image reconstruction and for a gradient waveform pre-emphasis. As test sequences, a gradient-echo sequence with phase-encoding gradient modulation and a gradient-echo sequence with a spiral read-out trajectory were implemented and subsequently applied on a structural phantom and in vivo head measurements. RESULTS: Image artifacts were successfully suppressed by applying the GSTF-based pre-emphasis. Equivalent results are achieved with images acquired using GSTF-based post-correction of the trajectory as a part of image reconstruction. In contrast, the pre-emphasis approach allows reconstruction using the initially intended trajectory. CONCLUSION: The artifact suppression shown for two sequences demonstrates that the GSTF can serve for a novel pre-emphasis. A pre-emphasis based on the GSTF information can be applied to any arbitrary sequence type.

Monoplanar gradient system for imaging with nonlinear gradients.

OBJECT: In this paper we present a monoplanar gradient system capable of imaging a volume comparable with that covered by linear gradient systems. Such a system has been designed and implemented. MATERIALS AND METHODS: Building such a system was made possible by relaxing the constraint of global linearity and replacing it with a requirement for local orthogonality. A framework was derived for optimization of local orthogonality within the physical boundaries and geometric constraints. Spatial encoding of magnetic fields was optimized for their local orthogonality over a large field of view. RESULTS: A coil design consisting of straight wire segments was optimized, implemented, and integrated into a 3T human scanner to show the feasibility of this approach. Initial MR images are shown and further applications of the derived optimization method and the nonlinear planar gradient system are discussed. CONCLUSION: Encoding fields generated by the prototype encoding system were shown to be locally orthogonal and able to encode a cylindrical volume sufficient for some abdomen imaging applications for humans.

Single-shot imaging with higher-dimensional encoding using magnetic field monitoring and concomitant field correction.

PURPOSE: PatLoc (Parallel Imaging Technique using Localized Gradients) accelerates imaging and introduces a resolution variation across the field-of-view. Higher-dimensional encoding employs more spatial encoding magnetic fields (SEMs) than the corresponding image dimensionality requires, e.g. by applying two quadratic and two linear spatial encoding magnetic fields to reconstruct a 2D image. Images acquired with higher-dimensional single-shot trajectories can exhibit strong artifacts and geometric distortions. In this work, the source of these artifacts is analyzed and a reliable correction strategy is derived. METHODS: A dynamic field camera was built for encoding field calibration. Concomitant fields of linear and nonlinear spatial encoding magnetic fields were analyzed. A combined basis consisting of spherical harmonics and concomitant terms was proposed and used for encoding field calibration and image reconstruction. RESULTS: A good agreement between the analytical solution for the concomitant fields and the magnetic field simulations of the custom-built PatLoc SEM coil was observed. Substantial image quality improvements were obtained using a dynamic field camera for encoding field calibration combined with the proposed combined basis. CONCLUSION: The importance of trajectory calibration for single-shot higher-dimensional encoding is demonstrated using the combined basis including spherical harmonics and concomitant terms, which treats the concomitant fields as an integral part of the encoding.

Simultaneously driven linear and nonlinear spatial encoding fields in MRI.

Spatial encoding in MRI is conventionally achieved by the application of switchable linear encoding fields. The general concept of the recently introduced PatLoc (Parallel Imaging Technique using Localized Gradients) encoding is to use nonlinear fields to achieve spatial encoding. Relaxing the requirement that the encoding fields must be linear may lead to improved gradient performance or reduced peripheral nerve stimulation. In this work, a custom-built insert coil capable of generating two independent quadratic encoding fields was driven with high-performance amplifiers within a clinical MR system. In combination with the three linear encoding fields, the combined hardware is capable of independently manipulating five spatial encoding fields. With the linear z-gradient used for slice-selection, there remain four separate channels to encode a 2D-image. To compare trajectories of such multidimensional encoding, the concept of a local k-space is developed. Through simulations, reconstructions using six gradient-encoding strategies were compared, including Cartesian encoding separately or simultaneously on both PatLoc and linear gradients as well as two versions of a radial-based in/out trajectory. Corresponding experiments confirmed that such multidimensional encoding is practically achievable and demonstrated that the new radial-based trajectory offers the PatLoc property of variable spatial resolution while maintaining finite resolution across the entire field-of-view.