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Hepatogastroenterology ; 48(42): 1743-5, 2001.
Artigo em Inglês | MEDLINE | ID: mdl-11813614

RESUMO

BACKGROUND/AIMS: To determine the role of p53 mutations on survival after pancreatoduodenectomy for adenocarcinoma of the pancreatic head. METHODOLOGY: Resected specimens were assessed for expression of wild-type or mutated p53. Survival of p53-negative and- positive patients was investigated, and differences noted at 0.05 level. RESULTS: Expression of wild-type p53 is associated with a significant improvement in overall survival, especially for patients without nodal metastases. CONCLUSIONS: Preoperative p53 determination could enable further patient selection for aggressive surgery.


Assuntos
Carcinoma Ductal de Mama/genética , Carcinoma Ductal de Mama/mortalidade , Genes p53/genética , Pancreatectomia , Neoplasias Pancreáticas/genética , Neoplasias Pancreáticas/mortalidade , Idoso , Carcinoma Ductal de Mama/patologia , Carcinoma Ductal de Mama/cirurgia , Feminino , Humanos , Masculino , Mutação , Estadiamento de Neoplasias , Neoplasias Pancreáticas/patologia , Neoplasias Pancreáticas/cirurgia , Análise de Sobrevida
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