Enantioselective Pd(II)-Pd(IV) catalysis utilizing a SPRIX ligand: efficient construction of chiral 3-oxy-tetrahydrofurans.

Novel enantioselective catalysis involving a Pd(II)-Pd(IV) cycle was developed by utilizing a SPRIX ligand. Treatment of alkenyl alcohols with a catalytic amount of Pd-SPRIX and TfOH in the presence of PhI(OAc)2 gave optically active 3-oxy-tetrahydrofuran derivatives in good yields.