RESUMO
The development of innovative nanosystems opens new perspectives for multidisciplinary applications at the frontier between materials science and nanomedicine. Here we present a novel hybrid nanosystem based on cytocompatible inorganic SiC/SiOx core/shell nanowires conjugated via click-chemistry procedures with an organic photosensitizer, a tetracarboxyphenyl porphyrin derivative. We show that this nanosystem is an efficient source of singlet oxygen for cell oxidative stress when irradiated with 6â MV X-Rays at low doses (0.4-2â Gy). The in-vitro clonogenic survival assay on lung adenocarcinoma cells shows that 12 days after irradiation at a dose of 2â Gy, the cell population is reduced by about 75% with respect to control cells. These results demonstrate that our approach is very efficient to enhance radiation therapy effects for cancer treatments.
Assuntos
Nanofios/química , Fármacos Fotossensibilizantes/química , Porfirinas/química , Compostos Inorgânicos de Carbono/química , Linhagem Celular Tumoral , Sobrevivência Celular/efeitos dos fármacos , Sobrevivência Celular/efeitos da radiação , Raios gama , Humanos , Neoplasias Pulmonares/tratamento farmacológico , Nanofios/ultraestrutura , Fotoquimioterapia , Fármacos Fotossensibilizantes/uso terapêutico , Fármacos Fotossensibilizantes/toxicidade , Compostos de Silício/química , Dióxido de Silício/químicaRESUMO
High sensitivity zinc oxide (ZnO) tetrapods (TPs) have been functionalized by nucleating cadmium sulphide (CdS) nanoparticles (NPs) directly on their surface with a spotted coverage thanks to an optimized synthesis in dimethylformamide (DMF). The obtained hybrid coupled material has been used to realize a gas sensing device with a highly porous nanostructured network, in which the proper alternation of ZnO-TPs and CdS-NPs gives rise to unconventional chemoresistive behaviours. Among the different tested gases and vapours, the sensor showed a unique fingerprint response-inversion between 300 °C and 400 °C only for nitrogen dioxide (NO2) and acetic acid (CH3COOH).