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Saudi J Kidney Dis Transpl ; 24(2): 309-14, 2013 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-23538355

RESUMO

We report a rare case of cytomegalovirus (CMV)-associated ischemic colitis and transverse myelitis (TM) occurring precociously after renal transplantation. A 57-year-old male was transplanted with a cadaveric kidney on 5 June 2009. The patient was CMV seropositive and the donor was seronegative. Transplantation was followed shortly by TM, which resulted in paraplegia. The results of magnetic resonance imaging of the spinal cord showed abnormalities. Twenty days after transplantation, he developed abdominal pain with melena and was diagnosed as having CMV-associated ischemic colitis confirmed by colonoscopy and biopsy. Serological data and identification of the viral genome by polymerase chain reaction were confirmatory for CMV. Treatment consisted of intravenous ganciclovir, followed by polyvalent immunoglobulin. The outcome was favorable. Symptomatic CMV infection is relatively common among the renal transplant population. Early colonoscopy is beneficial for making a quick diagnosis and therefore helps to institute a prompt management of CMV colitis. Myelitis is less common in transplant recipients and diagnosis, therefore, was more difficult.


Assuntos
Colite Isquêmica/etiologia , Infecções por Citomegalovirus/etiologia , Transplante de Rim/efeitos adversos , Mielite Transversa/etiologia , Dor Abdominal/etiologia , Antivirais/uso terapêutico , Biópsia , Colite Isquêmica/diagnóstico , Colite Isquêmica/tratamento farmacológico , Colite Isquêmica/virologia , Colonoscopia , Citomegalovirus/genética , Infecções por Citomegalovirus/diagnóstico , Infecções por Citomegalovirus/tratamento farmacológico , Infecções por Citomegalovirus/virologia , DNA Viral/análise , Ganciclovir/uso terapêutico , Humanos , Imunoglobulinas Intravenosas/uso terapêutico , Fatores Imunológicos/uso terapêutico , Imageamento por Ressonância Magnética , Masculino , Melena/etiologia , Pessoa de Meia-Idade , Mielite Transversa/diagnóstico , Mielite Transversa/tratamento farmacológico , Mielite Transversa/virologia , Reação em Cadeia da Polimerase , Valor Preditivo dos Testes , Resultado do Tratamento
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