RESUMO
OBJECTIVE: We evaluated ductal closure rates in preterm neonates with hemodynamically significant patent ductus arteriosus (hsPDA) who received paracetamol (PCM) as first-line therapy. METHODS: In this retrospective chart review, we included inborn preterm (< 37 weeks) neonates (January 2017-December 2021) with hsPDA (ductal diameter > 1.5 mm and left atrium-to-aortic root ratio (La/Ao > 1.4) who were treated with oral or intravenous PCM. Primary outcome was hsPDA closure (defined as small or no PDA) following 3-day treatment. Secondary outcomes were need for retreatment and surgical ligation, pulmonary hypertension (PH), and in-hospital morbidities. RESULTS: Out of 2784 preterm birth, 117 neonates were diagnosed with hsPDA. Out of 96 neonates who received PCM in the first course, 20 died before the completing the first course. The median (IQR) gestation and birth weight of neonates who received PCM were 28 (26, 29) weeks and 841 (714, 1039) g, respectively. Out of 76 neonates who completed treatment with first course of PCM (57 intravenous, 19 oral), 43 (56.6%) achieved successful closure and five (6.6%) developed PH. Out of 14 neonates who received a second course of PCM, 10 achieved closure of hsPDA while one neonate expired. CONCLUSION: Paracetamol is associated with successful closure of hsPDA in 56.6% of preterm neonates after one course and 70% of premies after two courses.
Assuntos
Acetaminofen , Permeabilidade do Canal Arterial , Recém-Nascido Prematuro , Centros de Atenção Terciária , Humanos , Permeabilidade do Canal Arterial/tratamento farmacológico , Acetaminofen/uso terapêutico , Recém-Nascido , Índia , Estudos Retrospectivos , Centros de Atenção Terciária/estatística & dados numéricos , Feminino , Masculino , Analgésicos não Narcóticos/uso terapêutico , Resultado do TratamentoRESUMO
The International League Against Epilepsy (ILAE) recently published an updated classification of seizures and epilepsy. This updated classification aims to have a better organized classification and ensure better understanding of terms, in addition to including new seizure types. As both seizures and epilepsy are important childhood conditions, we herein list some of the important aspects of the updated classification for the benefit of the general pediatricians. The full classifications are available at the ILAE website.
