Assuntos
Neoplasias da Mama/diagnóstico , Neoplasias da Mama/patologia , Tumores Neuroectodérmicos Primitivos/diagnóstico , Tumores Neuroectodérmicos Primitivos/patologia , Adulto , Neoplasias da Mama/cirurgia , Feminino , Histocitoquímica , Humanos , Microscopia , Tumores Neuroectodérmicos Primitivos/cirurgiaRESUMO
CONTEXT: Visceral leishmaniasis (VL) is endemic in India and may simulate and cause many hematological disorders like pancytopenia, myelofibrosis, myelodysplasia and hemophagocytosis. AIMS: The study aims to investigate the hematological manifestation of Visceral Leishmaniasis and associated changes that may be observed in bone marrow aspirate smears and biopsy which may warn a pathologist of possible infections. SETTINGS AND DESIGN: This is a retrospective study of 18 VL cases on B (b) one marrow aspirate and biopsy in the department of Pathology in a tertiary care teaching hospital in New Delhi. METHODS AND MATERIAL: Giemsa stained slides of bone marrow aspirates and hematoxylin and Eosin stained biopsy slides were reviewed in detail by two competent pathologists. All the findings were tabulated and discussed and comparisons made with the previous similar studies. RESULTS: Hyper cellular marrow, increased lymphocytes and plasma cells, marrow granulomas, hemophagocytosis, myelofibrosis, myelodysplasia and gelatinous transformation of the marrow were notable features the presence of which together or individually should caution a pathologist to search for Leishman Donovan (LD) bodies in patients especially in a non-endemic zone in a tropical country.
Assuntos
Medula Óssea/patologia , Leishmaniose Visceral/patologia , Adolescente , Adulto , Biópsia , Feminino , Histocitoquímica/métodos , Hospitais de Ensino , Humanos , Índia , Masculino , Microscopia/métodos , Estudos Retrospectivos , Adulto JovemAssuntos
Tumores Neuroectodérmicos Primitivos/patologia , Neoplasias Testiculares/patologia , Biomarcadores Tumorais/metabolismo , Biópsia por Agulha Fina , Pré-Escolar , Humanos , Imuno-Histoquímica , Masculino , Tumores Neuroectodérmicos Primitivos/metabolismo , Tumores Neuroectodérmicos Primitivos/cirurgia , Neoplasias Testiculares/metabolismo , Neoplasias Testiculares/cirurgiaAssuntos
Adenoma/patologia , Granuloma de Células Plasmáticas/patologia , Neoplasias Renais/patologia , Adenoma/complicações , Adenoma/metabolismo , Adulto , Biomarcadores Tumorais/metabolismo , Feminino , Granuloma de Células Plasmáticas/complicações , Granuloma de Células Plasmáticas/metabolismo , Humanos , Rim/diagnóstico por imagem , Rim/patologia , Rim/cirurgia , Neoplasias Renais/complicações , Neoplasias Renais/metabolismo , Nefrectomia , Tomografia Computadorizada por Raios XRESUMO
Teratomas of the head and neck are rare, benign neoplasms, usually presenting in the neonatal period and are often malignant with regard to their location. Teratomas occur with a frequency of one in 4,000 live births with head and neck teratomas accounting for <5% of the total. Extensive literature search has shown that there are only two cases congenital nasopharyngeal teratoma reported in India, and we report the third such case.
RESUMO
Intussusception is a relatively common cause of intestinal obstruction in children but a rare, and uncommon clinical entity in adults accounting for 1%. Lipoma accounts for 4% of all benign tumors of the gut. Most of these are seen in the large intestine, usually submucosal and around ileocecal valve. These are often asymptomatic. Though these lesions are benign, it continues to present difficulties in the preoperative differentiation between malignant and benign colonic neoplasm.
RESUMO
The presence of meningothelial elements along with abundant psammoma bodies indicates the presence of a benign meningioma within a teratoma. Recognition of meningioma arising in the setting of a teratoma is of prognostic significance, depending on the nature of this component and its spread beyond the organ of origin. We report a case of psammomatous meningioma in which meningothelial cells and psammoma bodies were both abundant and diffuse, allowing for the diagnosis of a meningioma.
Assuntos
Meningioma/patologia , Neoplasias Primárias Múltiplas/patologia , Neoplasias Ovarianas/patologia , Teratoma/patologia , Feminino , Humanos , Meningioma/cirurgia , Pessoa de Meia-Idade , Neoplasias Primárias Múltiplas/cirurgia , Neoplasias Ovarianas/cirurgia , Teratoma/cirurgia , Resultado do TratamentoRESUMO
We report the case of a 38-year-old Asian, Indian female with capillary hemangioma breast in coexistence with the commonly occurring fibroadenoma. Clinical examination of the breast revealed a 4 cm diameter lump. Mammography revealed a well defined slightly hypoechoic lesion with smooth contours. A lumpectomy was performed. Histopathology confirmed the diagnosis of a completely encapsulated fibroadenoma coexistent with a capillary hemangioma in the adjacent breast tissue. The rarity of literature on breast hemangioma especially capillary type with coexisting fibroadenoma deserves mention.
RESUMO
Primary salivary gland carcinoma with neuroendocrine differentiation is of rare occurrence, especially so in the parotid gland. Amongst the various reported primary tumors with neuroendocrine differentiation, acinic cell carcinoma (ACC) one such tumor. A 48 year old lady presented with a gradually increasing right infra-auricular swelling for a period of 1 year which enlarged suddenly in a short period. Contrast Enhanced Computed Tomography (CECT) suggested diagnosis of Pleomorphic Adenoma. Fine Needle Aspiration Cytology (FANC) yielded a cystic fluid suggesting a possibility of Warthin's tumor or Oncocytic lesion. Intraoperative findings were suggestive of a Warthin's tumor. Initial histopathological examination of the tumor was suggestive of neuroendocrine carcinoma. However, extensive sectioning revealed peripheral islands of ACC. Immunoexpression of S-100, Neuron specific Enolase (NSE), Chromogranin A and Synaptophysin confirmed the diagnosis. The possibility of neuroendocrine differentiation in a primary salivary gland tumor should be kept in mind whenever a salivary gland tumor shows only neuroendocrine histology.
Assuntos
Carcinoma de Células Acinares/patologia , Neoplasias Parotídeas/patologia , Adenolinfoma/patologia , Biópsia por Agulha Fina , Carcinoma de Células Acinares/cirurgia , Diagnóstico Diferencial , Feminino , Humanos , Imuno-Histoquímica , Pessoa de Meia-Idade , Neoplasias Parotídeas/cirurgiaRESUMO
Struma ovarii is a highly specialized and rare form of mature teratomas constituting 2% of all teratomas although small foci of thyroid tissue may be found in 5% to 15% of teratomas. Coexistence of this unusual germ cell tumor with ovarian epithelial tumors has been reported rarely; however, concomitant struma ovarii and serous cystadenofibroma has been mentioned in only 1 case report in the extensively searched medical literature. We report a rare occurrence of struma ovarii along with a serous cystadenofibroma in a 47-year-old woman.
Assuntos
Adenofibroma/patologia , Neoplasias Primárias Múltiplas/patologia , Neoplasias Ovarianas/patologia , Estruma Ovariano/patologia , Adenofibroma/cirurgia , Feminino , Humanos , Pessoa de Meia-Idade , Neoplasias Primárias Múltiplas/cirurgia , Neoplasias Ovarianas/cirurgia , Ovariectomia , Estruma Ovariano/cirurgiaAssuntos
Cistos/diagnóstico , Esplenopatias/diagnóstico , Adolescente , Cistos/cirurgia , Humanos , Masculino , Esplenopatias/cirurgiaRESUMO
The case of a 12 yr old female with bcr-abl positive chronic myeloid leukemia who subsequently developed a fatal AML-M6b (pure erythroleukemia) blast crisis is presented. The case is unique for its rarity of occurrence and for the striking resemblance that the circulating proerythroblasts showed to the giant cells characteristically seen in Parvovirus B19-induced acute pure red cell aplasia. This is, to the best of our knowledge, the first description of such cells in a blast crisis of chronic myeloid leukemia.
Assuntos
Crise Blástica/patologia , Eritroblastos/patologia , Leucemia Eritroblástica Aguda/patologia , Neoplasias Primárias Múltiplas/patologia , Antineoplásicos/uso terapêutico , Crise Blástica/metabolismo , Crise Blástica/terapia , Transfusão de Sangue , Criança , Feminino , Humanos , Hidroxiureia/uso terapêutico , Imuno-Histoquímica , Leucemia Eritroblástica Aguda/metabolismo , Leucemia Eritroblástica Aguda/terapia , Neoplasias Primárias Múltiplas/metabolismo , Neoplasias Primárias Múltiplas/terapiaRESUMO
Clitoromegaly (macroclitoris) can either be congenital or acquired. Intradermal nevus presenting as clitoromegaly in a child is extremely rare. Extensive Medline search has failed to reveal any published article on this. To the best of our knowledge, we report the first patient with this presentation in a 6-year-old child.
Assuntos
Clitóris/patologia , Nevo Intradérmico/patologia , Neoplasias Cutâneas/patologia , Criança , Diagnóstico Diferencial , Feminino , Humanos , Hipertrofia , Nevo Intradérmico/diagnóstico , Nevo Intradérmico/fisiopatologia , Nevo Intradérmico/cirurgia , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/fisiopatologia , Neoplasias Cutâneas/cirurgia , Resultado do TratamentoRESUMO
Langerhans cell histiocytosis is known to mimic many other conditions. We present two patients where anti-tubercular therapy was instituted when clinical and radiological features suggested tuberculosis. The correct diagnosis of histiocytosis was reached only on further work-up including immunohistochemistry following un-responsiveness to treatment. In retrospect it was felt that an inordinately high index of suspicion for tuberculosis, clinical and radiological overlap between the two entities, an urgency to start empirical therapy in a rapidly deteriorating patient and pathological similarities between epithelioid histiocytes and pathologic Langerhans cells led to the diagnostic and therapeutic errors.