Herpes zoster mRNA vaccine induces superior vaccine immunity over licensed vaccine in mice and rhesus macaques.

Herpes zoster remains an important global health issue and mainly occurs in aged and immunocompromised individuals with an early exposure history to Varicella Zoster Virus (VZV). Although the licensed vaccine Shingrix has remarkably high efficacy, undesired reactogenicity and increasing global demand causing vaccine shortage urged the development of improved or novel VZV vaccines. In this study, we developed a novel VZV mRNA vaccine candidate (named as ZOSAL) containing sequence-optimized mRNAs encoding full-length glycoprotein E encapsulated in an ionizable lipid nanoparticle. In mice and rhesus macaques, ZOSAL demonstrated superior immunogenicity and safety in multiple aspects over Shingrix, especially in the induction of strong T-cell immunity. Transcriptomic analysis revealed that both ZOSAL and Shingrix could robustly activate innate immune compartments, especially Type-I IFN signalling and antigen processing/presentation. Multivariate correlation analysis further identified several early factors of innate compartments that can predict the magnitude of T-cell responses, which further increased our understanding of the mode of action of two different VZV vaccine modalities. Collectively, our data demonstrated the superiority of VZV mRNA vaccine over licensed subunit vaccine. The mRNA platform therefore holds prospects for further investigations in next-generation VZV vaccine development.

Performance of Seven Land Surface Schemes in the WRFv4.3 Model for Simulating Precipitation in the Record-Breaking Meiyu Season Over the Yangtze-Huaihe River Valley in China.

In 2020, the Yangtze-Huai river valley (YHRV) experienced the highest record-breaking Meiyu season since 1961, which was mainly characterized by the longest duration of precipitation lasting from early-June to mid-July, with frequent heavy rainstorms that caused severe flooding and deaths in China. Many studies have investigated the causes of this Meiyu season and its evolution, but the accuracy of precipitation simulations has received little attention. It is important to provide more accurate precipitation forecasts to help prevent and reduce flood disasters, thereby facilitating the maintenance of a healthy and sustainable earth ecosystem. In this study, we determined the optimal scheme among seven land surface model (LSMs) schemes in the Weather Research and Forecasting model for simulating the precipitation in the Meiyu season during 2020 over the YHRV region. We also investigated the mechanisms in the different LSMs that might affect precipitation simulations in terms of water and energy cycling. The results showed that the simulated amounts of precipitation were higher under all LSMs than the observations. The main differences occurred in rainstorm areas (>12 mm/day), and the differences in low rainfall areas were not significant (<8 mm/day). Among all of the LSMs, the Simplified Simple Biosphere (SSiB) model obtained the best performance, with the lowest root mean square error and the highest correlation. The SSiB model even outperformed the Bayesian model averaging result. Finally, some factors responsible for the differences modeling results were investigated to understand the related physical mechanism.

Variations in global temperature and precipitation for the period of 1948 to 2010.

Climate change has impacts on both natural and human systems. Accurate information regarding variations in precipitation and temperature is essential for identifying and understanding these potential impacts. This research applied Mann-Kendall, rescaled range analysis and wave transform methods to analyze the trends and periodic properties of global and regional surface air temperature (SAT) and precipitation (PR) over the period of 1948 to 2010. The results show that 65.34% of the area studied exhibits significant warming trends (p < 0.05) while only 3.18% of the area exhibits significant cooling trends. The greatest warming trends are observed in Antarctica (0.32 °C per decade) and Middle Africa (0.21 °C per decade). Notably, 62.26% of the area became wetter, while 22.01% of the area shows drying trends. Northern Europe shows the largest precipitation increase, 12.49 mm per decade. Western Africa shows the fastest drying, -21.05 mm per decade. The rescaled range analysis reveals large areas that show persistent warming trends; this behavior in SAT is more obvious than that in PR. Wave transform results show that a 1-year period of SAT variation dominates in all regions, while inconsistent 0.5-year bands are observed in East Asia, Middle Africa, and Southeast Asia. In PR, significant power in the wavelet power spectrum at a 1-year period was observed in 17 regions, i.e., in all regions studied except Western Europe, where precipitation is instead characterized by 0.5-year and 0.25-year periods. Overall, the variations in SAT and PR can be consistent with the combined impacts of natural and anthropogenic factors, such as atmospheric concentrations of greenhouse gases, the internal variability of climate system, and volcanic eruptions.