Ultrasonic implant site preparation using piezosurgery: a multicenter case series study analyzing 3,579 implants with a 1- to 3-year follow-up.

This multicenter case series introduces an innovative ultrasonic implant site preparation (UISP) technique as an alternative to the use of traditional rotary instruments. A total of 3,579 implants were inserted in 1,885 subjects, and the sites were prepared using a specific ultrasonic device with a 1- to 3-year follow-up. No surgical complications related to the UISP protocol were reported for any of the implant sites. Seventy-eight implants (59 maxillary, 19 mandibular) failed within 5 months of insertion, for an overall osseointegration percentage of 97.82% (97.14% maxilla, 98.75% mandible). Three maxillary implants failed after 3 years of loading, with an overall implant survival rate of 97.74% (96.99% maxilla, 98.75% mandible).

Clinical and radiologic evaluation of 70 immediately loaded single implants in the maxillary esthetic zone: preliminary results after 1 year of functional loading.

PURPOSE: A key challenge in implant treatment in the esthetic zone is to provide patients with crowns and peri-implant mucosa that are in harmony with the adjacent teeth to restore both function and esthetics. The aim of the present study was to show the preliminary results of an immediate loading protocol in the maxillary esthetic zone that is designed to preserve the soft tissue. MATERIALS AND METHODS: Patients were treated with immediately loaded single-tooth implants (Seven, MIS). Implants were inserted in fresh postextraction sites or in single edentulous sites with clinically and radiologically healed bone. After 8 weeks of loading, the provisional crowns and abutments were modified as needed to enhance the esthetics of the gingival margins. Definitive restorations were delivered 4 to 6 months postoperatively. RESULTS: Seventy patients were treated; 25 implants were placed in fresh extraction sites, and the remaining 45 implants were inserted in healed single edentulous sites. All implants were stable, and radiographs showed complete osseointegration after 1 year of functional loading. CONCLUSIONS: The present study shows promising results for immediate loading of single implants. All implant sites fulfilled success criteria in terms of function and esthetics, and particularly promising results were seen following additional adjustments of the provisional restorations to preserve interdental papillae.

Immunohistochemical expression of CD3, CD20, CD45, CD68 and bcl-2 in oral squamous cell carcinoma.

OBJECTIVE: To study the main processes involved in oral squamous cell carcinoma (OSCC): apoptosis and inflammation. STUDY DESIGN: The immunohistochemical expression of bcl-2, CD3, CD20, CD45 and CD68 were studied by standard linked streptavidin-biotin horseradish peroxidase technique in 21 paraffin-embedded OSCC specimens in order to establish their possible correlation with the degree of tumoral differentiation. RESULTS: A trend was observed for the association of inflammatory infiltrate with the degree of tumor differentiation: well and moderately differentiated tumors tend to be associated to a dense inflammatory infiltrate (57.9% of cases), while poorly differentiated cancers seem to be associated to a low inflammatory infiltrate in 85.7% of cases. The most expressed molecule was CD68, followed by CD45, CD20 and CD3. Bcl-2 was low or moderately expressed, and immunostaining was more diffuse in moderately or poorly differentiated oral cancers. CONCLUSION: Inflammatory infiltrate and the degree of OSCC differentiation may be linked, but the specific role still remains unclear.

A comparative study of bone densitometry during osseointegration: piezoelectric surgery versus rotary protocols.

OBJECTIVES: To date, there have been no studies on the outcome of osseointegration of alveolar bone around dental implants inserted with piezoelectric osteotomy versus conventional osteotomy. The aim of this study was to compare the radiographic differences, through evaluation of peri-implant bone density, between implant insertion using traditional surgical technique and piezoelectric technique. METHOD AND MATERIALS: Forty patients were selected whose treatment consisted of a minimum of two implants placed in nonpathologic native bone. A single type of implant surface (SLA) was chosen. The implants were placed following the manufacturer protocol for traditional surgical technique and piezoelectric technique. Radiographs were taken following surgery and 30, 60, and 90 days after surgery. The bone density was studied with the densitometry application. RESULTS AND CONCLUSION: All patients completed the study period with success. Despite a limited number of treated patients, the results of this pilot study demonstrated that (1) piezoelectric implant site preparation promotes better bone density and osteogenesis, and (2) the piezoelectric technique is predictable, with a 100% success rate in this study.

Keratosis follicularis of the oral mucosa with oral squamous cell carcinoma.

Darier's disease or keratosis follicularis is a genodermatosis which may involve the oral mucosa. Malignant degeneration is rare. We report the first case of the combined manifestation of oral keratosis follicularis and oral squamous cell carcinoma and discuss the possible involvement of ATP2A2 (located in 12q23-24.1) which encodes the sarco/endoplasmic reticulum Ca(2+)-ATP isoform 2 (SERCA2), in the pathogenesis.