RESUMO
Complete resolution of a cerebral gumma can take place after massive corticosteroid treatment. Such a result in patients not known as syphilitic can be misleading and hamper the identification of the true nature of the lesion.
Assuntos
Corticosteroides/uso terapêutico , Neurossífilis/tratamento farmacológico , Adulto , Feminino , Humanos , Imageamento por Ressonância Magnética , Neurossífilis/diagnóstico , Fatores de RiscoAssuntos
Transplante de Rim , Neoplasias Bucais/etiologia , Complicações Pós-Operatórias , Sarcoma de Kaposi/etiologia , Neoplasias Cutâneas/etiologia , Adulto , Ciclosporinas/efeitos adversos , Feminino , Humanos , Terapia de Imunossupressão/efeitos adversos , Masculino , Pessoa de Meia-Idade , Neoplasias Bucais/patologia , Sarcoma de Kaposi/patologia , Neoplasias Cutâneas/patologiaAssuntos
Betametasona/análogos & derivados , Dermatite Seborreica/tratamento farmacológico , Psoríase/tratamento farmacológico , Salicilatos/uso terapêutico , Adolescente , Adulto , Betametasona/uso terapêutico , Criança , Combinação de Medicamentos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Ácido SalicílicoRESUMO
Hereditary angioedema (HAE) is a disease related to a complement disorder, namely a deficiency of C1 esterase inhibitor. Complement-split products are implicated in the regulation of the immune response, and we have compared some immunologic parameters between HAE and normal individuals. T-lymphocytes with receptors for IgG were increased in HAE, but no difference in T-cell suppressor activity for B-cells was detected. Furthermore, increased IgG receptor expression was not accompanied by any significant changes in the ratios of OKT4- and OKT8-defined antigens. Numbers of peripheral mononuclear cells (MNC) detected by alpha-naphthyl acetate esterase (ANAE) staining positivity were not significantly modified in HAE patients, although there was a trend toward higher absolute numbers of them showing paranuclear localization of ANAE. HAE patients had significantly reduced numbers of Langerhans cells (LC) showing different morphology and localization patterns. These observations are discussed in terms of differential membrane arrangements related to particular stages of cell activation, possibly attributable to continual complement activation resulting from a lack of control by C1 esterase inhibitor.