RESUMO
This study investigated Plasmodium spp. infection in free-ranging neotropical primates from Brazilian Amazon regions under the impact of major anthropogenic actions. Blood samples from 19 new world primates were collected and analyzed with microscopic and molecular procedures. The prevalence of Plasmodium infection was 21.0% (4/19) and PCR positive samples were identified as P. brasilianum. Considering the social-economic changes that the Amazon is facing, the prevalence of P. brasilianum infection highlights the necessity to closely monitor the movement of both human and non-human primate populations, in order to mitigate pathogen exposure and the introduction of new agents into previously naïve areas.
Assuntos
Anopheles/parasitologia , Reservatórios de Doenças , Insetos Vetores/parasitologia , Malária/parasitologia , Plasmodium/patogenicidade , Doenças dos Primatas/parasitologia , Animais , Brasil/epidemiologia , Doenças Endêmicas/estatística & dados numéricos , Humanos , Malária/epidemiologia , Malária/transmissão , Plasmodium/isolamento & purificação , Doenças dos Primatas/epidemiologia , Clima TropicalRESUMO
Erythromycin, a reversal agent in multidrug-resistant cancer, was assayed in chloroquine resistance modulation. The in vitro microtechnique for drug susceptibility was employed using two freshly isolates of Plasmodium falciparum from North of Brazil. The antimalarial effect of the drug was confirmed, with an IC50 estimates near the usual antimicrobial therapy concentration, and a significant statistical modulating action was observed for one isolate
