Traitement chirurgical du Mal de Pott et de ses séquelles au Centre Hospitalier de l'Ordre de Malte Dakar / Surgical treatm ent of Pott's diseaseand its sequelae at the Hospital of the Order of Malta/Daka

Introduction. Evaluer les résultats du traitement chirurgical du Mal de Pott et de ses séquelles au Centre hospitalier de l'ordre de Malte de Dakar. Patients et méthodes. Nous présentons les résultats préliminaires d'une série consécutive de 23 patients (13 hommes et 10 femmes) d'âge moyen de 32,35 ans [6 ­70 ans] présentant des Maux de Pott ou de leurs séquelles nécessitant un traitement chirurgical. L'échelle d'incapacité d'Oswestry, l'échelle visuelle analogique et le score ASIA ont été utilisés pour l'évaluation clinique. Les radiographies pré opératoires, post opératoires et au recul ont été utilisés pour les résultats anatomiques. Tous ces patients ont été opérés selon trois stratégies opératoires sur une période de 67 mois (Avril 2014- Novembre 2019). Nous avons réalisé une laminectomie arthrodèse postérieure dans 52,2% ; une laminectomie plus OTP et arthrodèse postérieure dans 43,5% ; une discectomie et hémicorporectomie avec arthrodèse antérieure par plaque vissée de Roy Camille à l'étage cervical dans 4,3%. Résultats. La symptomatologie était dominée par la douleur rachidienne, la cyphose et les troubles neurologiques. La cyphose post opératoire était significativement améliorée (la moyenne passe de 48,52° en pré opératoire à 17,09° en post opératoire). On a obtenu 100% de fusion vertébrale. On note une nette amélioration de la douleur rachidienne (avec une baisse au recul de 55,44 points pour l'OID et de 5,66 pour l'EVA) ; 78,3% des patients étaient très satisfaits, 17,4% satisfaits et 4,3% mécontents. Conclusion. Le traitement chirurgical du Mal de Pott et de ses séquelles a fortement amélioré les rachis au Centre hospitalier de l'Ordre de Malte.

Introduction. To evaluate the results of the surgical treatment of Pott's disease and its sequelae at the Hospital Center of the Order of Malta in Dakar. Patients and methods. We present the preliminary results of a consecutive series of 23 patients (13 men and 10 women) with an average age of 32.35 years [6-70 years] presenting with Pott's disease or its sequelae requiring treatment. surgical treatment. Oswestry Disability Scale, Visual Analogue Scale and ASIA score were used for clinical assessment. Preoperative, postoperative and followup radiographs were used for anatomical results. All these patients were operated according to three operating strategies over a period of 67 months (April 2014- November 2019). We performed posterior laminectomy-arthrodesis in 52.2%; laminectomy plus OTP and posterior arthrodesis in 43.5%; discectomy and hemicorpectomy with anterior arthrodesis by Roy Camille screwed plate at the cervical level in 4.3%. Results. The symptomatology was dominated by spinal pain, kyphosis and neurological disorders. Postoperative kyphosis was significantly improved (the average goes from 48.52° preoperatively to 17.09° postoperatively). We got 100% spinal fusion. There is a clear improvement in spinal pain (with a drop at follow-up of 55.44 points for the OID and 5.66 for the EVA); 78.3% of patients were very satisfied, 17.4% satisfied and 4.3% dissatisfied. Conclusion. The surgical treatment of Pott's disease and its sequelae greatly improved the spines at the Hospital Center of the Order of Malta.

Development of pH-based ElecFET biosensors for lactate ion detection.

In this work, we report on ElecFET (Electrochemical Field Effect Transistor) devices potentially of interest for the detection of different molecules in solution. ElecFET are electrochemical microsensors in liquid phase, based on two elements: (i) a pH-sensitive chemical field effect transistor (pH-ChemFET) and (ii) a metallic microelectrode deposited around the sensitive gate. The coexistence of these two elements combines (i) potentiometric and (ii) amperometric detection effects at the microscale. Design, fabrication and experimental validation of ElecFETs based on silicon and polymer micro-technologies, are reported. We first demonstrate the detection of hydrogen peroxide (H(2)O(2)) in solution, showing a sensitivity of 5 mV/mM in the [10-100 mM] concentration range. The ElecFET concept is then extended to the detection of glucose and lactate in the [1-30 mM] and [1-6 mM] concentration range respectively. The sensitivities are between 2-6 mV/mM and 8-20 mV/mM respectively.

[Cephalic duodenopancreatectomy at the Hopital du Point G, Bamako]. / La duodenopancreatectomie cephalique (DPC) a l'Hopital du Point G, Bamako.

PURPOSE OF THE STUDY: to bring back the clinical and therapeutic aspects of 6 cases of DPC in the service of surgery A of the hospital of the POINT G. PATIENTS AND METHODS: descriptive retrospective study of 5 years and 6 months in the service. All the patients presenting a duodéno-pancreatic malignant tumour treated by DPC with histological diagnostic confirmation were included in the study. The palliative techniques of biliary and digestive derivations were not retained. RESULTS: 6 files of patients were collected. The average age of the patients was 63 years. The average time of consultation was 8 months. The abdominal pains, the jaundice and the cutaneous prurit were the reasons for consultation of first order. The functional signs were the cutaneous prurit and vomiting, the faded saddles (2 cases, 33.3%), and the dark urines (a case, 16,7% of the cases). The seat of pain was epigastric among 3 patients (50%), diffuse with epigastric starting point in a case, pain of the right hypochondre in one case. An epigastric mass was palpated by 4 patients (66,6%). A hepatomegaly and a large blister were palpated once (16,7% of the cases). High blood amylase rates are noted by 4 patients (66,7%). The rates of bilirubine free and total in blood were very high. The echographic image was that of a mass of the head of the pancreas and a dilation of the bile ducts will intra and extrahepatic as well as channel of Wirsung (4 cases, 66.7%). The computer tomodensitometry did not objectify local vascular invasion, hepatic metastases, or of ascite. The tomodensitometric images of the lesions were a cystic tumour of the head of the pancreas (one case), a pancreatic tumour + cholestase (one case), a tumour of the head of the pancreas with compression of duodenum (4 cases). Classes ASA II (4, 66.7%) and III (2, 33.3%) were only represented. The procedures of resection were practised according to the technique of WHIPPLE or its alternatives. The ganglionic clearing out related to the 5 classical chains. The early continuations were simple for 4 patients (66,6%). A case of parietal suppuration, a pancreatic leak (operated again at J3) and a death were recorded. The average duration of the hospital stay was 16 days. Two patients died between 0 and 3 months into postoperative, and 2 others died between the 3rd month (33,33%) and the 10th month (33,3%). The results of the histological examination were 4 cases of adenocarcinomists of the pancreas (66,6%), a adenocarcinomist inflammatory and necrotic, a fairly differentiated adenocarcinomist. CONCLUSION: the tumours of the head of the pancreas very often diagnosed at a late stage are of weak frequency in our context of exercise. The DPC is burdened with a made morbidity of pancréato-jejunal dents. The rate of survival at 5 years remains around 5%.

Ethnobotanical survey and antibacterial activity of some plants used in Guinean traditional medicine.

A total of 418 healers have been interviewed in Guinea, a coastal country of West Africa, ranging between 7 degrees 30 and 12 degrees 30 of northern latitude and 8 degrees and 15 degrees of western longitude. Plant species used by the local inhabitants to treat infectious diseases were identified using ethnobotanical, ethnographic and taxonomic methods. During these investigations, 218 plants were registered, of which the following were the most frequently used: Erythrina senegalensis, Bridelia ferruginea, Crossopteryx febrifuga, Ximenia americana, Annona senegalensis, Cochlospermum tinctorium, Cochlospermum planchonii, Lantana camara, Costus afer, Psidium guajava, Terminalia glaucescens, Uapaca somon and Swartzia madagascariensis. Most plants, and especially the leaves, were essentially used as a decoction. In order to assess antibacterial activity, 190 recipes were prepared and biologically tested, among which six showed activity (minimal inhibitory concentration<125 microg/ml) against Bacillus cereus, Mycobacterium fortuitum, Staphylococcus aureus, or Candida albicans, i.e., Entada africana, Chlorophora regia, Erythrina senegalensis, Harrisonia abyssinica, Uvaria tomentosa, and a mixture of six plants consisting of Swartzia madagascariensis, Isoberlinia doka, Annona senegalensis, Gardenia ternifolia, Terminalia glaucescens and Erythrina senegalensis.

[Using CT to diagnose brain tumors at the Point G Hospital in Mali]. / Apports de la tomodensitometie dans la prise en charge des tumeurs cerebrales a l'Hopital du Point G (Mali).

The authors report 27 cases of cerebral tumours in 22 men and 5 women age 1 to 81. Clinical symptoms were dominated by cranial hypertension (59.3%), focal motor impairment involving cranial nerves (51.9%.) and seizures due to epilepsy (44.4%). The main tumors detected with CT scan include glyoma (.5 cases), craniopharyngioma (3 cases), adenoma (3 cases), medulloblastoma (3 cases), and metastasis (3 cases). The supra tentoriel was predominant (76.9%). Neurosurgery was performed in 6 patients and 21 cases received medical treatment. We fund 13 cases of death. In conclasion, cerebral tumours are very severe pathologies because of the high mortality associated with. CT scan has contributed to diagnose the lesions, show their topography and to determinte the histological nature. Neurosurgery is necessary for the treatment of these lesions.

[Cancer of the head of the pancreas: clinical, diagnostic and therapeutic aspects at Bamako]. / Cancer du pancreas cepihalique: aspects cliniques, diagnostiques et thérapeutiques à Bamako.

OBJECT: to determine the relative frequency of the cancer of the head of the pancreas in our structures of 3(ieme) reference to Bamako as well as the diagnostic and therapeutic aspects. PATIENTS AND METHODS: It is about a descriptive retrospective study in the services of general surgery of the Hospital of the Point G and the Hospital Gabriel Touré from January 2000 to June 2004. Were included in the study all the patients presenting a malignant tumour of the head of the pancreas having been confirmed by a histological examination. RESULTS: 26 patients were listed, that is to say 0.3% of the hospitalizations for the period of the study. The reason for hospitalization was an abdominal mass in 57.14% of the cases. The average age of the patients was 58 years. The sex ratio was 4:2 in favour of the men. Clinical signs of cholestase with type of jaundice frankly accompanied by prurit were present at the clinical examination in 95.24% of the cases. The other signs were the pain, a palpable mass, a ascite representing respectively 71.43%, 66.67%, 23.81% of the cases, Abdomino-pelvic echography allowed the diagnosis in 90% of the cases and the scanner in 100% of the cases. The rate of bilirubine total and free as well as the rates of transaminases (ASAT, ALAT) was high in respectively 95.24% and 85.71% of the cases, The curative therapy consisted of a duodeno-pancreatectomy in 9 cases (39.16% of the cases). A double palliative bilio-digestive derivation was carried out in treatment in 53.84 of the cases, The histological type was the adenocarcinomist in 95.24% of the cases. The rate of survival to 1 year was 10.5% in the event of curative treatment and 5.3% in the event of palliative treatment. CONCLUSION: The diagnosis of cancers of the head of the pancreas is posed at late stages in our structures. The DPC is feasible but the rate of resecability is weak. The palliative treatment can help to improve the quality of life of the patients.

[Assessment of endoscopic surgery at the Hospital of Point G in Bamako]. / Bilan de 45 mois d'activites de coeliochirurgie a Bamako.

PURPOSE OF THE STUDY: To carry out the first 45 months assessment of activities of coeliochirurgie at the hospital of the Point G Bamako. PATIENTS AND METHODS: It was about a retrospective study of 45 months carried out in the service of surgery "A" of the CHU of the Point G All the patients having undergone an intervention by technique coeliochirurgicale with or without conversion into conventional surgery were retained. RESULTS: for 45 months, 426 patients profited from the technique, i.e., 18.99% of the patients operated in the service for this period. The most frequent indications were the gynaecological surgery (61.27%), with pathologies tubaires, followed digestive surgery (33.33%) with the lithiasic cholécystite and acute appendicitis. The parietal surgery and the "staging" of cancerous pathologies represented respectively (3.05%) and (2.35%). Conversion into conventional surgery related to 7.5% of patients. We listed few accidents and incidental per operational. The duration of the hospital stay shorter was compared with that of the conventional surgery. The operational continuations were simple in 97.9% of the cases. CONCLUSION: the coeliochirurgie is realizable and reliable under the conditions of exercise of the surgery in Mali. The indications are to be measured in order to avoid the complications inherent in the technique and to progress positively. The benefit of the technique is ensured for the patient and the hospital.

[Contribution of ultrasound in the diagnosis of the complications of intramuscular injection in children]. / Apport de l'echographie dans le diagnostic des complications de l'injection intramusculaire chez l'enfant.

During a prospective study conducted at the rehabilitation Center of the physically handicapped persons and at the mother-child Hospital in Bamako, the authors report 50 cases of neuromuscular complications of the quinine intramuscular injection in the child. The scan revealed muscular calcifications in 37 cases (740%), abscesses, in 7 cases (14%) and muscular inflammations in 6 cases (12%). Xray of the affected limb was not systematic: it has been performed in four children in the case of a subjacent bone involment. It showed calcifications in two cases. If muscular abscess is easily diagnosed by clinical exam it is not the case for calcifications. The scan allows to set up a precise mapping of the muscular lesions, to determine their type and size. It also helps the clinicians in their therapeutic attitude. Medical treatment associated with rehabilitation has been carried out in 40 patients (80%) and surgery in 10 patients (20%).

[Value of computer tomography in the managment of brain injuries]. / Apport de la tomodensitométrie dans la prise en charge des traumatismes cranio-encéphauques: expérience de L'Hopital de Bamako.

The purpose of this prospective study conducted from January 2001 to December 2001 was to ascertain the value of computer tomography for evaluation of brain injuries. Computer tomography was performed using a Toshiba X VID system with contiguous 5 mm axial sections through the posterior fossa and 10 mm contiguous axial sections through the subtentorial region without contrast injection. A total of 107 patients with brain injuries were enrolled over the one-year study period. These patients accounted for 0.8% of all admissions to surgical emergency unit of Gabriel Toure Hospital in Bamako, Mali. The predominant age group for brain injuries was the 20- to 29-year-old group (35 cases). The male-to-female sex ratio was 5:1. Vehicular accident was the most frequent cause of brain injury (76 cases). Trauma was severe in 48 patients with a Glasgow score less than 8. Coma occurred immediately after injury in 90 cases. Ventricular hemorrhage led to coma in 100% of cases whereas brain hemorrhage and hematoma led to coma in 93.3% and 83.3% of cases respectively. Treatment was medical in 99 cases and neurosurgical in 8. The mortality rate was 34% and the morbidity rate (permanent sequels) was 36%. Computer tomography is a valuable tool for therapeutic decision-making in medico-surgical emergencies involving brain injuries.

[Evaluation of the cost of stroke management in Dakar, Senegal]. / Evaluation du coût de prise en charge des accidents vasculaires cérébraux à Dakar--Senegal.

The purpose of this one-year cross-sectional study conducted in 1997 was to estimate the direct cost of stroke management in the Neurology Department of Fann University Hospital in Dakar, Senegal. Data were collected about the type of care services required and related spending. Cost analysis was made in CFA Francs (CFAF), the Senegalese currency (1 USD = 500 CFAF in 1997). A total of 1260 patients were hospitalized in the department including 383 for stroke (30.4%). Mean age was 60.8 +/- 14.2 years and men accounted for 49.2% of the population. The mortality rate was 46.2% among hospitalized patients. A total of 33,573 medical acts were carried out including 12,052 (35.9%) for stroke management. The direct cost of stroke management was 32,614,442 CFAF with a mean cost of 78,426 CFAF per patient. The cost was 18,839 CFAF in the patient care unit (57.8%) and 4,954,635 CFAF in the neuroradiology unit (15.2%). The cost of health care personnel was 19,373,172 CFAF (59.4%) and the cost for drugs and other medical products was 8,253,246 CFAF. Health education programs aimed at increasing awareness of risk factors are needed to reduce the cost of stroke management in this difficult economic period.

[Fractionation of the total extract of Khaya senegalensis Barks. Value of the formulation of an anti-inflammatory ointment]. / Fractionnement de l'extrait des ecorces de Khaya senegalensis: intérêt dans la formulation d'une pommade anti-inflammatoire.

The aim of this work was to compare the anti-inflammatory activity of the total extract of Khaya senegalensis Barks and its different fractions for optimizing the active ingredients which be used in the ointment formulation. For that, a fractionation was performed followed by anti-inflammatory tests based on the method of the croton oil induced oedema. Three fractions were obtained and the comparison of their activity with the one of the total extract has shown the following results: 37.10%, 45.65%, 22.30% and 22.36% respectively for the extract, fraction n1, fraction n2 and fraction n3. The statistical analysis ofthe results (Student Test; p = 0.05) have revealed that the fraction nl is significatively more active than the others. However, there was not a significant difference between the inhibition induced by the fraction n1 and the total extact one, even the mean value of this latter is lower. Therefore, it seems enough to use the total extract as active ingredient for developing an anti-inflammatory ointment.

[Aetiological aspects of neurological diseases in Dakar: follow-up after 10 years (1986-1995)]. / Aspects etiologiques des affections neurologiques à Dakar: bilan de 10 années (1986-1995).

Because of the apparition of new risk factors and numerous progresses in investigation methods, authors take stock of neurological diseases of patients admitted in Clinique Neurologique of Fann during the last ten years. The 8539 cases repartition is as followed: 4736 males and 3803 female. Their ages ranged between 3 and 80 years with 2130 deaths corresponding to 24.94%. Annual mean of admission is 853 +/- 42 cases. Aetiological data are: stroke (3910 cases 45.78% with 60.56% of death). The following is peripheral neuropathieswith 714 cases(8.61%) and the spinal cord compression with 692 cases (8.10%). Comparision of frequencies of different aetiologies with those of previous studies shows that the small capacity of the neurological department is a restricting factor for the entry frequencies of neurological patients; the principal pathologies got small variations from one decade to another. In the opposite, some aetiologies have disappeared (neurological syphilitis, trypanosomiasis, neurocyticercosis, cerebral mycosis). Some eatiologies remain unprecised (infectious diseases, peripheral neuropathies, degenerative diseases).