Tratamiento del autismo con estimulación magnética: bases neurofisiológicas / Autism treatment with magnetic stimulation: neurophysiological bases

RESUMEN El Autismo y los Trastornos del Espectro Autista son trastornos del neurodesarrollo. Los períodos críticos del neurodesarrollo finalizan en la consolidación estructural de un circuito neuronal y su conectividad. Esos períodos están regulados por interneuronas inhibitorias que expresan la proteína parvalbúmina. La ausencia de parvalbúmina en el Autismo conlleva a un desequilibrio de la relación excitación inhibición. La hiperexcitabilidad impiden la adecuada sincronización y conectividad con otras regiones cerebrales. La estimulación magnética cerebral en el Autismo y los TEA intentan modificar las anormalidades neurofisiológicas de los circuitos comprometidos.

SUMMARY Autism and Autism Spectrum Disorders are neurodevelopmental disorders. The critical periods of neurodevelopment end in the structural consolidation of a neuronal circuit and its connectivity. These periods are regulated by inhibitory interneurons that express the parvalbumin protein. The absence of parvalbumin in Autism leads to an imbalance of the excitation inhibition ratio. Hyperexcitability prevents adequate synchronization and connectivity with other brain regions. Transcraneal Magnetic Stimulation in Autism and ASD attempts to modify the neurophysiological abnormalities of the compromised circuits.

Routine same-day discharge after acute or interval appendectomy in children: a prospective study.

HYPOTHESIS: The outcomes of and parental satisfaction with same-day discharge in children undergoing laparoscopic appendectomy warrant making it the usual and customary pathway. DESIGN: Prospective cohort study. SETTING: Tertiary care children's hospital. PATIENTS: Between July 1, 2010, and March 30, 2011, a total of 207 children were considered for same-day discharge after acute or interval laparoscopic appendectomy. The all-in-one single-incision single-instrument technique was used in 95.7% of children. INTERVENTIONS: Same-day discharge vs overnight admission. MAIN OUTCOME MEASURES: Operative details, postoperative length of stay, adverse events, and parental satisfaction. RESULTS: Of 207 consecutive children undergoing acute (n = 186) or interval (n = 21) appendectomy, 162 (78.3%) were discharged on the day of surgery. The remaining 45 children were admitted overnight because the hour was too late for discharge in 35 (77.8%), medical indications dictated admission in 5 (11.1%), and social reasons required admission in 5 (11.1%). In all the children, oral medication alone was used for postoperative pain. The complication rates were similar in the same-day discharge group (8.0%) and in the admitted group (6.6%), as were the rates of urgent postoperative visits (7.4% vs 4.4%%) and the readmission rates (2.5% vs 2.2%) (P > .05 for all). The same-day discharge group had a reduced postoperative length of stay compared with the admitted group (mean, 5 vs 16 hours, P < .05). At the time of discharge, most parents (87.0%) stated they were happy with the expeditious discharge, whereas 8.0% indicated they felt nervous but were ultimately satisfied. In retrospect, 8 of 162 parents (4.9%) were not sure early discharge was best, but only 1 parent would insist on admission if faced with the situation again. CONCLUSION: Routine same-day discharge after pediatric appendectomy seems safe, with good parental satisfaction.

A prospective study of safety and satisfaction with same-day discharge after laparoscopic appendectomy for acute appendicitis.

BACKGROUND/PURPOSE: This study examines the safety and patient satisfaction in discharging children undergoing laparoscopic appendectomy (LapAppy) for acute appendicitis on the day of surgery. METHODS: After institutional review board approval, data were collected prospectively for 158 consecutive patients undergoing LapAppy for simple appendicitis. Time from operation to discharge and complications were analyzed. At follow-up, parents completed a satisfaction survey. The Student t test was used for statistical analysis. RESULTS: Laparoscopic appendectomy was performed in 158 children ranging from age 2 to 19 years (mean, 12 years) over a 6-month period. Single-port, single-instrument LapAppy was possible in 152 patients (96%). Eighty percent of patients (n = 126) were discharged on the day of surgery, a mean of 4.8 hours postoperatively (range, 1-12 hours). Of the remaining 32, 24 (75%) were admitted because the operation ended too late for postoperative discharge; 3 (9%), for medical reasons; and 5 (16%), when the families declined to leave. One hundred nine parents (87%) whose children went home postoperatively stated that they were happy with the expeditious discharge, whereas 17 (13%) felt nervous. In addition, 116 parents (92%) stated that, in retrospect, same-day discharge was preferable, whereas 10 parents (8%) were not sure that it was the best decision. None, however, would insist on admission if faced with the situation again. There were no major complications and no significant difference in the rate of umbilical wound infections for same-day discharge patients (2%) and admitted patients (3%). CONCLUSION: Routine same-day discharge after pediatric LapAppy for acute appendicitis is safe, with good parent satisfaction.