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BackgroundSevere Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a virus that causes COVID-19, which has become a worldwide pandemic. However, until now, there is no vaccine or specific drug to prevent or treat COVID-19. ObjectivesTo find out the effective treatment as an antiviral agent for COVID-19, to determine the correlation between sociodemography with clinical outcomes and duration of treatment, and to determine the relationship between comorbidities with clinical outcomes and duration of treatment for COVID-19 patients. MethodsA prospective cohort study was conducted in this study. This study included only confirmed COVID-19 patients who were admitted to the hospital during April-May 2020. Convenience sampling was used to select 103 patients, but only 72 patients were suitable for inclusion. ResultsThe survival analysis for COVID-19 patients using the Kaplan Meier method showed that patients receiving Oseltamivir + Hydroxychloroquine had an average survival rate of about 83% after undergoing treatment for about ten days. Gender (p = 0.450) and age (p = 0.226) did not have a significant correlation with the duration of treatment for COVID-19 patients. Gender (p = 0.174) and age (p = 0.065) also did not have a significant correlation with clinical outcome of COVID-19 patients. Comorbidities showed a significant correlation with duration of treatment (p = 0.002) and clinical outcome (p = 0.014) of COVID-19 patients. ConclusionThe most effective antiviral agent in this study based on treatment duration was the combination of Oseltamivir + Hydroxychloroquine. The higher the patients average treatment duration, the lower the average survival rate for COVID-19 patients.
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@#Haemodialysis is a continuous treatment provided to patients with chronic kidney disease as a replacement for renal function. It is important to assess the quality of life among these patients. The aim of this study was to evaluate quality of life among patients on haemodialysis using an Indonesian version of the KDQoL-SF24 questionnaire. This is a cohort observational study that included 145 haemodialysis patients in a haemodialysis centre in Jakarta, Indonesia. A translated and validated version of the KDQoL-SF24 was used in this survey. The participants in this study had lower mean scores than the standard form in the following 6 components: burden of kidney disease (44.22±33.23), cognitive function (74.94±20.32), sleep (57.07±24.15), patient satisfaction (60.11±18.56), role-physical (26.21±44.01), emotional well-being (69.19±24.25) and role-emotional (40.69±49.18). A significant relationship was found between sexual function, physical functioning, role emotional and age among haemodialysis patients (P <0.05). Based on the overall health rating from the KDQoL-SF24, the mean and standard deviation for the 21- to 30-year-old age group was lower than the standard form. The burden of kidney disease, cognitive function, sleep, patient satisfaction, role-physical, emotional well-being and role-emotional component scores were low for haemodialysis patients in Indonesia compared to the standard form. Additionally, age significantly affected sexual function, physical functioning and role-emotional.
