1.
Biochem Soc Trans
; 33(Pt 6): 1382-4, 2005 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16246124
RESUMO
The ER (endoplasmic reticulum) is the site of protein folding for all eukaryotic secreted and plasma membrane proteins. Disulphide bonds are formed in many of these proteins through a dithiol-disulphide exchange chain comprising two types of protein catalysts: PDI (protein disulphide-isomerase) and ERO (ER oxidoreductase) proteins. This review will examine what we know about ERO function, and will then consider ERO interactions and their implications for mammalian oxidative protein folding.