RESUMO
N,O-heterocycles containing the dicarbonyl ring play a significant role in heterocyclic and therapeutic chemistry. Since the discovery of 1,3-diketones, numerous research works have been achieved regarding the synthesis and its chemical reactivity. In this review, we have described the most relevant publications involving ß-diketone compounds published during the period between 2018 to date. In addition, we include the 1,3-diketones-based heterocyclic compounds prepared by various synthetic methodologies.
Assuntos
Compostos Heterocíclicos , CetonasRESUMO
Heterocyclic compounds containing the quinoline ring play a significant role in organic synthesis and therapeutic chemistry. Polyfunctionalized quinolines have attracted the attention of many research groups, especially those who work on drug discovery and development. These derivatives have been widely explored by the research biochemists and are reported to possess wide biological activities. This review focuses on the recent progress in the synthesis of heterocyclic compounds based-quinoline and their potential biological activities.
Assuntos
Anti-Infecciosos/uso terapêutico , Compostos Heterocíclicos/uso terapêutico , Quinolinas/química , Animais , Anti-Infecciosos/química , Compostos Heterocíclicos/química , HumanosRESUMO
Spontaneous subarachnoid hemorrhage (SAH) is often a devastating condition and a significant cause of worldwide morbidity and mortality. Because the percentage of senior citizens is increasing in many countries and because of the increased incidence of SAH in elderly patients, ruptured intracranial aneurysm is an increasingly frequent pathology in western countries. Twenty years ago, older people were considered to have such a poor prognosis that they were frequently excluded from active treatment on the unique basis of their advanced age. Improving results published in recent studies showed that the classic fatalistic attitude associated with age and intracranial aneurysm (IA) should be reconsidered. Therefore, because of improvements in surgical results and neuro-intensive care, the appearance of interventional neuroradiology, and more aggressive rehabilitation programs, the management of ruptured IA in the elderly is changing. This article aims to review epidemiology, emphasize the specific aspects of the disease in the elderly, and present the current management of SAH in an elderly population.
Assuntos
Aneurisma Roto/diagnóstico , Aneurisma Roto/terapia , Aneurisma Intracraniano/diagnóstico , Aneurisma Intracraniano/terapia , Hemorragia Subaracnóidea/epidemiologia , Hemorragia Subaracnóidea/terapia , Fatores Etários , Idoso , Aneurisma Roto/complicações , Feminino , Humanos , Aneurisma Intracraniano/complicações , Masculino , Fatores Sexuais , Hemorragia Subaracnóidea/etiologiaRESUMO
Wide-neck renal artery aneurysms are difficult or impossible to treat endovascularly with Guglielmi detachable coils. The authors report a case of embolization of a wide-neck aneurysm of the right renal artery bifurcation with the combination of a TrisPan coil (neck-bridge device developed by Boston Scientific Target) and Guglielmi detachable coils. Complete occlusion of the aneurysm with preservation of the renal artery and its branches was shown with angiography performed after the procedure.
