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6.
9.
Science ; 153(3740): 1127-8, 1966 Sep 02.
Artigo em Inglês | MEDLINE | ID: mdl-5918576

RESUMO

Diabetes (db), which occurred in an inbred strain of mouse, is inherited as a unit autosomal recessive and is characterized by a metabolic disturbance resembling diabetes mellitus in man. Abnormal deposition of fat at 3 to 4 weeks of age is followed shortly by hyperglycemia, polyuria, and glycosuria. Accompanying morphological changes in the islets of Langerhans suggest neogenesis to compensate for insulin depletion.


Assuntos
Diabetes Mellitus/genética , Mutação , Animais , Glicemia , Peso Corporal , Feminino , Masculino , Camundongos
10.
Science ; 151(3707): 205-6, 1966 Jan 14.
Artigo em Inglês | MEDLINE | ID: mdl-5907909

RESUMO

Examination of 1.5 million mice yielded natural mutation rates estimnated from 5.2 million gene reproductions at five specific coat-color loci. The average rates were 11.1 x 10(-6) for forward mutations and 2.7 x 10(-6) for reverse mutations. Differences between the frequencies of mutations at the individual loci were evident.


Assuntos
Genes , Camundongos , Mutação , Animais , Feminino , Masculino
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