1.
Org Biomol Chem
; 1(13): 2364-76, 2003 Jul 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12945710
RESUMO
Alkylation reactions using alpha-halolactams or lactam enolates derived from bicyclic lactam templates can proceed with high endo- or exo- diastereoselectivity respectively. In the latter case, stereochemical correction by means of enolate generation and hindered phenol quench is possible with moderate efficiency. This protocol has been applied to the synthesis of protected penmacric acid and its analogues.