1.
J Antibiot (Tokyo)
; 56(7): 639-46, 2003 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-14513907
RESUMO
A new secondary metabolite was detected in the culture extract of Streptomyces sp. AK 409 by HPLC-diode-array screening. The metabolite was identified as pyrocoll, which is known to be a constituent of cigarette smoke. Pyrocoll is known as a synthetic compound, but until now had not been isolated as a natural product from a microorganism. The compound showed biological activity against various Arthrobacter strains, filamentous fungi, several pathogenic protozoa, and some human tumor cell lines.