RESUMO
BACKGROUND: The purpose of this study was to evaluate the effects of intravenous zoledronic acid applied systemically on osseointegration of dental implants and the surrounding bone mineral density (BMD) in the ovariectomized rats. MATERIAL AND METHODS: 36 rats were divided into three groups: control (CTRL), ovariectomy (OVX), and ovariectomy-zoledronic acid (OVX/ZOL). The rats in the CTRL group underwent sham surgery, while rats in OVX and OVX / ZOL group underwent ovariectomy. After 12 weeks, rats from OVX / ZOL were injected with 0.04 mg/ kg ZOL intravenously once a week for 6 weeks. The rats from CTRL and OVX groups were injected with 0.9% NaCl. Implants were placed in the left tibia. After 8 weeks, rats were sacrificed and tibia bones were removed for radiodensitometric examination. Digital radiographs of bones' lateral surface were taken. The BMD was measured by using radiographic analysis software. RESULTS: Statistically significant differences were found between all groups (p < 0.05). While highest mean BMD values were observed in the CTRL group, the lowest were in the OVX group. CONCLUSIONS: The systemic use of ZOL has increased the bone density around the implants inserted osteoporotic rat tibia
Assuntos
Animais , Ratos , Densitometria/métodos , Densidade Óssea , Implantes Dentários , Difosfonatos/efeitos adversos , Ovariectomia , Modelos Animais de Doenças , Osteoporose/complicaçõesAssuntos
Sangue , Implantação Dentária Endóssea/métodos , Levantamento do Assoalho do Seio Maxilar/métodos , Adulto , Feminino , Seguimentos , Humanos , Arcada Parcialmente Edêntula/cirurgia , Seio Maxilar/cirurgia , Osseointegração/fisiologia , Osteogênese/fisiologia , Osteotomia/métodos , Cicatrização/fisiologiaRESUMO
OBJECTIVE: The aim of this study was to evaluate whether zoledronic acid improves post-implant osseointegration in an ovariectomized rat model. MATERIALS AND METHODS: A total of 36 female Wistar rats were subdivided into three groups: control (CTRL), ovariectomized (OVX) and ovariectomized + zoledronic acid (OVX/ZOL). Both OVX and OVX/ZOL groups underwent ovariectomy procedures, while the CTRL group received a sham operation. After a 90-day waiting period following surgery, the OVX/ZOL group received a weekly intravenous injection of 0.04 mg/kg zoledronic acid over a period of 6 weeks. The CTRL and OVX groups received intravenous injections of 0.9% NaCl, and the injections were administered with a dosing schedule that was identical to that of the OVX/ZOL group. After completing the 6-week injection regimen, every group received a titanium implant that was 1.6 mm in diameter by 4 mm in length, which was placed in the proximal metaphysis of the left tibia. All of the rats were sacrificed after 60 days and the tibia bones were harvested and processed for histological evaluation. RESULTS: The percentage of bone-implant contact (BIC) varied significantly between groups. Histomorphometric analysis demonstrated that BIC was significantly higher in the OVX/ZOL group than in the OVX group. CONCLUSIONS: Systemic zoledronic acid improved tibial titanium implant osseointegration in an oestrogen-deficient rat model.
